Abstract: The present work revolves around the protection and adaption of the Hacienda Perodias, an old farmhouse from the XVII century that is located in southwest Colombia. Besides being part of the nation’s rural built heritage, this building complex is connected also to the processes of evangelization and slave trade carried out at that time in South America. In order to illustrate how profound this embodied memory is translated into today’s social and cultural dynamics, this work is organized into three parts. The first, standing from a broader scale, covers the socio-geographical scenario in which this typology of building, the Casa de Hacienda, emerged and the social meanings that have been attached to it throughout time. Next, entering the scale of the constructed object, the second part focuses on the geographical, historical and architectural dimensions of the farmhouse in addition to the analysis of its current condition. All this is in order to properly understand the scope of the adaptation possibilities that this object that has been abandoned for more than two decades may have, opportunities that are contained in the final part of this work. In a quest to re-signify the collective memory linked to its spaces, the third and final part presents the proposed intervention of the Hacienda as a large eco-park, a refuge for wildlife and low-impact human activities, which lies at its heart the architectural complex of Perodias, now revitalised as a community centre. By giving a new life to this site, the project would seek to protect both a built heritage represented in its architecture and the cultural values shared by the surrounding communities, whose history can also be found linked to the hacienda. As a new centre for the transmission of ancestral knowledge and cultural expressions that in turn aims to enhance the capacities and opportunities of its inhabitants, the Perodias hacienda would finally be reborn.

Resumen: Esta investigación doctoral artística se centra en los sonidos culinarios que resuenan cuando la comida es implementada como mecanismo de resistencia política y social frente a circunstancias de adversidad, precariedad y de desplazamiento y dislocación territorial. La comida, utilizada como herramienta de resistencia, ha sido abordada por varios artistas, incluidos Sabor Clandestino en Bolivia, Fátima Kadumy en Palestina y María Buenaventura y Elena Villamil en Colombia. Estos sonidos, que comúnmente son pasados por alto e ignorados tanto en la literatura culinaria y la música, en esta investigación brindan pistas importantes sobre cómo opera la resistencia política en la contemporaneidad, considerando teorías sobre las políticas del sonido de Brandon LaBelle y Salomé Voegelin, y teorías sobre lo político y lo alimentario de Jane Bennett. Las piezas de arte sonoro y la investigación teórica sobre la comida como herramienta política y la resistencia en el arte, desarrolladas en esta investigación hacen un aporte original y significativo al conocimiento de la práctica del arte sónico y gastronómico en la contemporaneidad. Este proyecto presenta una metodología artística innovadora y original llamada Arte Sonoro Culinario Colaborativo (CCSA), que considera al sonido y la gastronomía como sensibilidades intersubjetiva y estratégica, explorando la conexión multisensorial entre el oído, el olfato y el gusto.

Abstract: In the present work, theoretical and experimental analysis of the thermal performance of flat plate pulsating heat pipes, made of copper, are presented. The pulsating heat pipes were manufactured using an innovative fabrication process for this application, the diffusion bonding. For this purpose, a special oven was used, available in Labtucal, that provides high temperature, high pressure and high vacuum conditions, which allows the fabrication of monolithic pieces with high reliability. Plates of equal external size were used, in which the internal channels were modified. Different geometries were applied, including the variation of the number of channels for the same overall dimensions (density increase), modifications of the surface finishing (roughness) and addition of lateral grooves at evaporator section. Flat plate pulsating heat pipes were tested under different operating conditions, such as tilt angles, heat input levels, and filling ratios, concluding that higher roughness or grooves at evaporator zone enhance the thermal performance of the devices, as start-up time, thermal resistance and thermal stability. However, the most relevant parameters, to decrease the dependence of the gravity in the operation of the pulsating heat pipe, are the number of channels and the working fluid filling ratios. A mathematical model, based on electrical circuit analogy, is constructed, taking into consideration the activation energy. Model validation was made with the experimental date obtained from the devices developed in this thesis. The model presented a maximum error of 25-30%, at vertical bottom heat mode and vertical top heat mode. The main contributions of this Ph.D. thesis are: the development of modified pulsating heat pipes using effective thermal improvements; the production of a reliable fabrication process compatible with the proposed thermal enhancements and, finally, a model that can be used as a design tool for pulsating heat pipes fabricated from machined plates. Resumen: En el presente trabajo, se realiza un análisis teórico y experimental del desempeño térmico de tubos de calor pulsantes de placa plana, fabricados en cobre. Los tubos de calor pulsantes fueron fabricados utilizando un proceso de fabricación innovador para esta aplicación, la difusión vinculación. Para ello se utilizó un horno especial, disponible en Labtucal, que proporciona alta temperatura, alta presión y alto vacío, lo que permite la fabricación de piezas monolíticas de alta confiabilidad. Se utilizaron placas de igual tamaño externo, en las que el Se modificaron los canales internos. Se aplicaron diferentes geometrías, incluyendo la variación de el número de canales para las mismas dimensiones generales (aumento de densidad), modificaciones del acabado superficial (rugosidad) y adición de ranuras laterales en la sección del evaporador. placa plana Los tubos de calor pulsantes se probaron en diferentes condiciones de funcionamiento, como ángulos de inclinación, calor suministrado, relaciones de llenado, concluyendo que una mayor rugosidad o ranuras en la zona del evaporador mejora el rendimiento térmico de los dispositivos, como el tiempo de inicio de operación, la resistencia térmica y la estabilidad de la temperatura. Sin embargo, los parámetros más relevantes, para disminuir la dependencia de la gravedad en el funcionamiento del tubo de calor pulsante, fueron el número de canales y las proporciones del llenado de fluido de trabajo. Se construye un modelo matemático, basado en la analogía del circuito eléctrico, tomando en Consideración la energía de activación. La validación del modelo se realizó con los datos experimentales obtenidos a partir de los dispositivos desarrollados en esta tesis. Las principales contribuciones de este doctorado tesis son: el desarrollo de tubos de calor pulsantes modificados utilizando mejoras térmicasla producción de un proceso de fabricación confiable y un modelo que se puede utilizar como herramienta de diseño.

Abstract: This qualitative research examines what sense of responsibility lower-ranking former perpetrators of paramilitary violence in Colombia elaborate in their confessional narratives for versiones libres, (freestatement hearings) a legal truth-seeking mechanism set in 2005 as part of a transitional justice process known as Justicia y Paz. Drawing from a critique against the confusion between ethical and judicial categories, this work assumes a relational-dialogical approach from where responsibility is understood as response-ability, or a person’s ability-to-respond. It looks into how an agent elaborates his responses in an attempt to connect not only with his criminal act (accountability) and with the transgressed norm, (imputability) but also with the individual(s) affected by their actions. The following questions guided this inquiry: 1) What responses were given by low-ranking ex-paramilitaries in judicial settings regarding their past actions? 2) What rationales for the violence perpetrated were included in those responses? And 3) What aspects may have influenced their confessions? A content analysis of a sample of versiones libres of four low-ranking former commanders was conducted, as well as qualitative interviews, and the observation of several sessions of the legal proceedings. Two themes were identified in their responses: 1) that all of them “just followed orders” from higher-ranking members of a chain of command; and 2) that they “believed too much” in local informants when planning and selecting the targets of their actions. Thus, they claim for themselves a higher-moral ground from where they question the terror perpetrated, yet their support to the paramilitary countersubversive cause is not confronted. This work contributes to the field of transitional justice in furthering an understanding of the psychosocial dimensions of post-conflict processes, and by shifting focus from high-level former perpetrators to the experiences of those with lower profiles who enacted the violence on the ground. Resumen: Esta investigación cualitativa examina cuál es el sentido de responsabilidad que elaboran antiguos miembros de bajo rango de los paramilitares en Colombia, como parte de sus narrativas confesionales durante las versiones libres, un mecanismo de justicia transitional implementado en 2005. A partir de una crítica a la confusión entre categorías éticas y judiciales, este trabajo asume un enfoque relacional-dialógico desde donde la responsabilidad se entiende como habilidad-para-responder. Así, se examina cómo un agente elabora su respuesta en un intento de conectarse no sólo con el acto criminal (en inglés, accountability) y con la ley transgredida (imputabilidad), sino también con los sujetos afectados por sus acciones. Las preguntas que guiaron este trabajo fueron: 1) ¿Cuáles fueron las respuestas que ex-paramilitares de bajo rango dieron por sus acciones criminales? 2) ¿Cuáles fueron las justificaciones por la violencia perpetrada que fueron incluidas en tales respuestas? Y 3) ¿Qué aspectos pueden haber influido sus confesiones? Es estudio incluyó un análisis de contenido de versiones libres de cuatro exparamilitares de bajo rango del Bloque Sur Putumayo, así como entrevistas cualitativas y la observación de varias versiones libres. Dos temas fueron identificados: 1) Que ellos sólo ""seguían órdenes"" de sus superiores, y 2) que ellos ""le creyeron mucho"" a informantes locales en la planeación de sus acciones. Así, los ex-paramilitares asumen un plano moral superior desde el que cuestionan el terror que perpetraron, pero desde el que no confrontan la ideología paramilitar que propició tales acciones. Esta investigación avanza en el entendimiento de las dimensiones psicosociales de la justicia transicional entre los ex-combatientes de bajo rango que ejecutaron acciones violentas masivas.

Abstract: Extinction learning and specifically the renewal effect has enabled for decades an insight into the complex dynamics of learning processes. Although context represents a critical stimulus in extinction learning, what constitutes a context and how it is represented is still not fully understood. Under the frame of the “Collaborative Research Center SFB 1280”, this master’s thesis established a functional experimental paradigm, on an open arena for context control experiments with birds. For this purpose, three pigeons were trained on a discrimination task following an ABA extinction-renewal protocol in two separate experiments. Three distinctive levels of contextual stimuli were tested in experiment 1: spatial awareness, local visual information and global visual information. Experiment 2 used modified versions of the spatial and local contexts. Results suggest a stronger renewal response for the local condition in both experiments and a medium renewal response for the spatial condition. The global condition barely produced any renewal. Manipulations on saliency and continuity of contextual stimuli provided evidence for context formation based on associative learning rules rather than relevant physical properties of contextual stimuli. Overall, the findings in this thesis support the assumption of no real distinction between cues and context.

Abstract: Antibiotic resistance is driven by selection, but how a bacterial strain’s evolutionary history shapes drug-resistance remains an open question. Here we reconstruct the genetic and evolutionary mechanisms of carbapenem resistance in a clinical isolate of Klebsiella. A combination of short and long read sequencing, machine learning, genetic and enzymatic analyses established that this carbapenem-resistant strain carries no carbapenemase-encoding genes. Genetic reconstruction of the resistance phenotype confirmed that two distinct genetic loci are necessary for the strain to acquire carbapenem resistance. Experimental evolution of the carbapenem-resistant strains in growth conditions without the antibiotic revealed that both loci confer a significant cost, and are readily lost by de novo mutation resulting in the rapid evolution of a carbapenem-sensitive phenotype. Thus, historical contingency - a patient’s treatment history - can shape the evolution of antibiotic resistance and suggests that the strategic combinations of antibiotics could direct the evolution of low-fitness, drug-resistant genotypes.

Abstract: The cell envelope is essential for the survival and adaptation of bacteria. Bacterial membrane proteins include the major porins that mediate the influx of nutrients and several classes of antimicrobial drugs. Consequently, membrane remodelling is closely linked to antimicrobial resistance (AMR). Knowledge of bacterial membrane protein biogenesis and turnover underpins our understanding of bacterial membrane remodelling and the consequences that this process has in the evolution of AMR phenotypes. At the population level, the evolution of phenotypes is a reversible process, and we can use these insights to deploy evolutionary principles to resensitize bacteria to existing antimicrobial drugs. In our opinion, fundamental knowledge is opening a new way of thinking towards sustainable solutions to the mounting crisis in AMR. Here we discuss what is known about outer-membrane remodelling in bacteria and how the process could be targeted as a means to restore sensitivity to antimicrobial drugs. Bacteriophages are highlighted as a powerful means to exert this control over membrane remodelling but they require careful selection so as to reverse, and not exacerbate AMR phenotypes.

Resumen: Las iniciativas socialmente responsables son generadoras indiscutibles de un mayor nivel de sentido de pertenencia de los empleados como miembros de una organización. Este fenómeno, a su vez impulsa resultados favorables en los niveles individual, grupal, organizacional e incluso institucional. El presente estudio analiza la asociación existente entre responsabilidad social empresarial e identificación organizacional de los empleados, con el objetivo de ilustrar el sentidopráctico de dicho vínculo causal. Para ello, se parte de un proceso preliminar de análisis bibliométrico y tamizaje cualitativo, que selecciona las conclusiones de trabajos empíricos influyentes en la literatura relevante con respecto al tópico en cuestión. Como consecuencia, el estudio converge en un decálogo de implicaciones útiles para gerentes y profesionales de recursos humanos que, en el terreno, determina los alcances de dicha relación en el ambiente organizacional real. De esta manera, se permite el aprovechamiento de las contribuciones teóricas relevantes en el área de estudio particular, y lo pone a disposición de la práctica gerencial. Abstract: Socially responsible initiatives are undisputed generators of a higher level of sense of belonging of employees as members of an organization. This phenomenon, in turn, promotes favorable results at the individual, group, organizational and even institutional level. The present work analyzes the association between corporate social responsibility and organizational identification of employees. It also illustrates the practical sense of such causal association. To achieve this, the work starts from a preliminary process of bibliometric analysis and screening, which selects the conclusions of influential empirical works in the relevant literature regarding the topic at issue. As a consecuence, the work converge in a decalogue of valuable implications for managers and human resources professionals, wichf in the field determines the scope of the abovementioned phenomenon in a regular organizational environment. In this way, the work allows the use of relevant theoretical contributions in the particular area of study and puts it a disposal of the managerial practice.

Resumen: La imagen de una institución de educación superior (IES) es considerada como un elemento estratégico para proyectar y dar a conocer los valores, las acciones, y en últimas, la razón de ser de la entidad respectiva. Por ello, algunas instituciones educativas se han inclinado por adentrase en un proceso de transformación de imagen en aras de posicionarse de mejor manera y lograr proyectar a sus stakeholders lo que realmente se desea. El presente trabajo tiene como propósito desarrollar, de manera preliminar, una revision sistemática de literatura sobre el tema de imagen y transformación de imagen institucional, haciendo especial énfasis en IES. Igualmente, se incluyen algunos conceptos relevantes relacionados con el tópico estudiado, así como los puntos de vista de algunos autores especializados en el área de estudio. En ese orden de ideas, el trabajo pretende ser un referente teórico inicial para eventuales evaluaciones de cambio o fortalecimiento de imagen de IES o sus unidades institucionales. Adicionalmente, permite soportar otros mecanismos de valoración para posibilitar la toma de decisiones relacionadas con la medición y el cuidado de la imagen institucional. Abstract: The image of a higher education institution (HEI) is considered as a strategic element to project and publicize the values, actions, and ultimately, the reason for being of the respective entity. For this reason, some educational institutions have been inclined to enter into a process of image transformation in order to position themselves in a better way and manage to project what is really desired to their stakeholders. The purpose of this paper is to develop, in a preliminary way, a systematic review of the literature on the subject of image and transformation of institutional image, with special emphasis on HEIs. Likewise, some relevant concepts related to the topic studied are included, as well as the points of view of some authors specialized in the area of study. In that order of ideas, the work intends to be an initial theoretical reference for eventual evaluations of change or strengthening of the image of HEIs or their institutional units. Additionally, it supports other assessment mechanisms to enable decision-making related to the measurement and care of the institutional image.

Resumen: El teletrabajo puede ser considerado una innovación organizacional, que en la actualidad ha adquirido una gran notoriedad debido al crecimiento exponencial en su ritmo de implementación. Aunque estudios previos se han centrado en diferentes resultados del teletrabajo, su impacto sobre el comportamiento innovador es un tópico de reciente investigación. En este sentido, el presente trabajo tiene como objetivo presentar una revisión de literatura sobre el tópico del comportamiento innovador y el entorno del teletrabajo. Asimismo, se plantea la exploración y clasificación de los antecedentes del comportamiento innovador. Sus resultados dan cuenta de la pertinencia del tópico en mención, así como de las claras oportunidades que futuras investigaciones podrían aprovechar para ampliar el conocimiento existente. Abstract: Teleworking can be considered an organizational innovation, which has currently acquired great notoriety due to the exponential growth in its rate of implementation. Although previous studies have focused on different outcomes of telework, its impact on innovative behavior is a topic of recent research. In this sense, this paper aims to present a literature review on the topic of innovative behavior and the teleworking environment. Likewise, the exploration and classification of the antecedents of innovative behavior is proposed. Their results show the relevance of the topic in question, as well as the clear opportunities that future research could take advantage of to expand existing knowledge.