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Image-guided programming of electrical settings in patients with Parkinson’s disease treated with bilateral subthalamic stimulation and suboptimal outcome

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Año de publicación 2022
Idioma Inglés

Descripción: Abstract: Background: Deep brain stimulation (DBS) surgery is a treatment in the advanced stage of Parkinson's disease (PD). Despite close follow-up, multiple evaluations, and several months of timeconsuming programming sessions, the clinical response may not be optimal in some cases. Imageguided programming (I-GP) could help optimize programming sessions with better clinical outcomes. Objective: To evaluate clinical and quality of life (QoL) outcomes with I-GP in PD patients with DBS of the subthalamic nucleus (STN) and suboptimal clinical improvement and refractory symptoms to conventional clinical programming. Methods: A prospective study in 16 patients with a diagnosis of PD with STN-DBS and remaining adverse effects or symptoms despite a clinical programming adjustment. We simulate potentially effective stimulation based on volume tissue activated (VTA) using commercially available software tools. Clinical outcomes were assessed with motor and quality of life scales. Results: The most frequent suboptimal symptom was gait disorder 33.3% (n=9), residual motor symptoms 25.9%(n=7), and speech 25.9%(n=7). Statistically significant results (p=0.001) were found after I-GP with change in the global Deep Brain Stimulation – Impairment score (41%), The 8- item version of the Parkinson's Disease Questionnaire (47%), EuroQol visual analogue scale (62%), and motor scale (24%). Conclusions: In suboptimal cases of patients with PD and STN-DBS, especially with ongoing and residual motor symptoms, I-GP could be useful to optimize the programming of DBS and improve patients' QoL.
Citación recomendada (normas APA)
: Viviana Torres Ballesteros, "Image-guided programming of electrical settings in patients with Parkinson’s disease treated with bilateral subthalamic stimulation and suboptimal outcome", Colombia:-, 2022. Consultado en línea en la Biblioteca Digital de Bogotá (https://www.bibliotecadigitaldebogota.gov.co/resources/3711698/), el día 2025-01-21.

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- Otros
- Medicina
Derechos de uso Derechos reservados
Fuente Biblioteca Virtual Banco de la República
Términos y condiciones de uso Más información aquí
Año de publicación 2022
Formato PDF
Cobertura Colombia

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Image-guided programming of electrical settings in patients with Parkinson’s disease treated with bilateral subthalamic stimulation and suboptimal outcome

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Image-guided programming of electrical settings in patients with Parkinson’s disease treated with bilateral subthalamic stimulation and suboptimal outcome

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