Abstract: At the present time, climate change and antimicrobial resistance are considered as the most critical threats, affecting human, animal, plant, and environmental health. Although these terms may initially appear different, they are interconnected and share similarities in their causes (human interventions and natural cycles), health, and societal consequences. Climate change is associated through direct and indirect pathways with an increase in infectious diseases. Nonetheless, the association between global warming and antimicrobial resistance requires a comprehensive summary of evidence exploring it. Methods: A literature review was conducted to identify and describe the association between climate change and the rapid emergence and spread of antimicrobial resistance. The search was conducted in the following databases: PubMed, Web of Science, Scopus, Embase, Epistemonikos, and Google Scholar. The search period was restricted to articles published from January 2010 to June 2021. Additionally, a snowballing approach was conducted to identify any additional papers. Data extraction included study location, weather factors, environmental elements, antibiotics, and bacteria analysed, as well as the results. Results: 29 articles were included (ten literature or systematic reviews, eight experimental, six ecological, four observational, and one quasi-experimental). In terms of location, all the studies were conducted in countries between 35° and 75° north latitude. The results suggested some evidence of the effects of climate change (alterations in temperature, precipitation, and humidity) on the emergence and rapid spread of antimicrobial resistance in different environments (water, soil, cryosphere, and air). Temperature was described as a main effect of climate change that had effects on antibiotic resistance (increasing bacteria growth, altering metabolism, inducing crossprotection, and facilitating horizontal gene transfer between bacteria). Additionally, results also described the association between altered rain patterns and humidity and antimicrobial resistance, through the runoff of antibiotic molecules or the transport of antibiotic resistance mechanisms to other areas. Conclusions: This literature review has underscored the association between climate change and antimicrobial resistance. According to the results shown in the selected studies, the alterations in weather factors resulting from climate change have varying effects on the emergence and spread of antibiotic resistance. However, further research is imperative to decipher the complex interactions between other environmental processes, pollutants, patterns of antibiotic consumption, wastewater, animal migration, and regions below the latitudes covered in this literature review.

Abstract: Background: Multidrug resistant TB cases have been on the rise, risking advances in TB prevalence and control. Early diagnosis and targeted initial treatment are paramount for effective management and control of spreading of MDR/XDR-TB cases Methods: 161 isolates from patients with L-J culture confirmed TB in Lima, Peru, were tested with MODS+ assay, the diagnostic test and Sensititre, the reference standard. Analysis of growth patterns of bacteria in both methods were used to determine susceptibility/resistance of each isolate to three first line and six second line anti-TB agents, using two different critical concentrations (CC) for each antibiotic. Results: Agreement between susceptibility profiles and operational characteristics of diagnostic test yielded high performance and strong agreement with rifampicin 1μg/ml (agreement percent 90%, Kappa value 0.80) and amikacin 1μg/ml (agreement percent 96%, Kappa value 0.81), moderate for isoniazid 0.4μg/ml (agreement percent 89.4%, Kappa value 0.78), moxifloxacin at both CC’s 0.5μg/ml and 0.25μg/ml (agreement percent 93 and kappa values 0.73 for both), levofloxacin 2μg/ml (agreement 93%, kappa 0.69) and amikacin 2μg/ml (agreement 96%, Kappa 0.81), minimal for levofloxacin at CC 1.5μg/ml (agreement 90%, kappa 0.57) kanamycin at both CC’s 10μg/ml and 5μg/ml (agreement 87%, kappa 0.52) and ethionamide 5μg/ml (agreement 89%, kappa 0.46), weak for PAS 10μg/ml (agreement percent 93.9, kappa value 0.29), and none for ethambutol (Kappa value 0.02 for CC 10μg/ml, 0.07 for CC 5μg/ml). Conclusions: MODS+ assay is a cost-effective option for the diagnosis of TB and MDR/XDRTB, specially, in low resource settings with high TB incidence. Further operational research using lower CC’s, results read on different days and placed in settings with high and low TB and MDR/XDRTB burden could offer better sensitivities and wider applicability of results.

Background: Data are rare about the incidence of severe Fontan-associated liver disease (FALD) and its association with mortality. We sought to: (1) estimate the probability of developing severe FALD in patients who undergo the Fontan procedure (Fontan patients), compared with severe liver complications in patients with a ventricular septal defect; (2) assess the severe FALD-mortality association; and (3) identify risk factors for developing severe FALD. Methods and Results: Using the Quebec Congenital Heart Disease database, a total of 512 Fontan patients and 10232 patients with a ventricular septal defect were identified. Kaplan-Meier curves demonstrated significantly higher cumulative risk of severe FALD in Fontan patients (11.95% and 52.24% at 10 and 35years, respectively), than the risk of severe liver complica- tions in patients with a ventricular septal defect (0.50% and 2.75%, respectively). At 5years, the cumulative risk of death was 12.60% in patients with severe FALD versus 3.70% in Fontan patients without FALD (log-rank P=0.0171). Cox proportional hazard models identified significant associations between the development of severe FALD and congestive heart failure and supraventricular tachycardia, with hazard ratios (HRs) of 2.36 (95% CI, 1.38–4.02) and 2.45 (95% CI, 1.37–4.39), respectively. More recent Fontan completion was related to reduced risks of severe FALD, with an HR of 0.95 (95% CI, 0.93–0.97) for each more recent year. Conclusions: This large-scale population-based study documents that severe FALD in Fontan patients was associated with a >3-fold increase in mortality. The risk of FALD is time-dependent and can reach >50% by 35years after the Fontan operation. Conditions promoting poor Fontan hemodynamics were associated with severe FALD development.

Background: Post-stroke fatigue (PSF) is one of the most challenging clinical consequences to manage after stroke as no effective treatment has been developed. However, the mechanisms of PSF remain unclear. Aims: This study aimed to replicate Vecchio et al (2017) using resting-state EEG in stroke patients suffering from varying degrees of fatigue to describe the functional organisation within sensory and motor networks. Methods: Resting-state eyes-open EEG was recorded in 22 strokesurvivors. Upper limb functional tests (grip strength, Nine Hole Peg Test), symbol digit modalities test (SDTM), anxiety and depression scale (HADS), Fatigue Severity Scale (FSS-7), state fatigue, and Neurological Fatigue Index (NFI-stroke) were measured. Graph theory was used to calculate the small-world (SW) index. SW was calculated in four separate networks, motor and sensory within the left and right hemispheres. Exact low-resolution brain electromagnetic tomography (eLORETA) was applied using seven frequency bands (delta, theta, alpha1, alpha2, beta1, beta2, and gamma). Results: Correlation analysis demonstrated a positive association between SW in the right motor network in beta2 band and higher FSS-7 score and a negative correlation between SW in the left sensory network in alpha1 and higher state fatigue. Conclusion: Beta oscillations have been associated with top-down processes which are crucial for perceptual inference and alpha oscillations are involved in sensorimotor information processing. The interaction between the top-down and bottom-up processes, and perceived error explains the sensory attenuation model of fatigue. Our results were consistent this model of fatigue as stroke survivors had difficulty in attenuating the sensory input leading to higher perceived effort.

Abstract: Objective: Intestinal parasitic infections (IPIs) are a public health challenge in developing countries such as Colombia, causing anaemia and delayed growth and development in children. We aimed to estimate the geographical and prevalence trend of IPIs in the last 30years in school and preschool children in Colombia. Methods: We conducted a systematic review and meta-analysis. We identified potential manuscripts through PubMed, EMBASE, Web of Science, LILACS, Scielo and Google Scholar on the IPIs prevalence in school and preschool children in Colombia. Articles included in the qualitative analysis were published between 1990 and 2020 in English or Spanish and met the inclusion criteria. Subsequently, a random-effects meta-analysis, a meta-regression and a trend analysis were performed. Results: We identified 2292 articles; 109 were included in the qualitative review, and 79 articles were included in the meta-analysis. The estimated IPI prevalence was 55% (95% CI: 48–63). By age group, the prevalence in preschool children was 37% (95% CI: 26–49) and 66% (95% CI: 52–78) in schoolchildren. The prevalence by region was heterogeneous, with the Amazon being the highest (69%) and the Santanderes the lowest (28%). In the last 20years, the prevalence of helminthiasis has decreased (from 64.66% in 1990–1995 to 22.09% in 2016–2020). Conclusion: The prevalence of IPIs is high (>30%) in three of the seven regions in Colombia. Biannual administration of mass deworming in schoolchildren is recommended in the Amazon region. Public policies aiming to control IPIs should be reinforced. Further prevalence studies should include Cesar, Guaviare, Vichada and Vaupés, where the epidemiology of IPIs is unknown. Resumen: Objetivo: Las infecciones parasitarias intestinales (IPIs) son un desafío para la salud pública en los países en desarrollo como Colombia, ya que causan anemia y retraso en el crecimiento y desarrollo de los niños. El objetivo de este estudio fue estimar la tendencia de la prevalencia y la distribución geográfica de las IPIs en niños en edad escolar y preescolar en Colombia en los últimos 30 años. Métodos: Se llevó a cabo una revisión sistemática y un metaanálisis. Se identificaron estudios potenciales a través de PubMed, EMBASE, Web of Science, LILACS, Scielo y Google Scholar cuyo objetivo era estimar la prevalencia de las IPIs en niños en edad escolar y preescolar en Colombia. Se incluyeron artículos publicados entre 1990 y 2020, tanto en inglés como en español, que cumplieran con los criterios de inclusión. Posteriormente, se realizó un metaanálisis de efectos aleatorios, una meta-regresión y un análisis de tendencias. Resultados: Identificamos 2,292 artículos; 109 se incluyeron en la revisión cualitativa y 79 en el metaanálisis. La prevalencia estimada de las IPIs fue del 55% (IC del 95%: 48-63%). Según el grupo de edad, la prevalencia en niños preescolares fue del 37% (IC del 95%: 26-49%), y en niños en edad escolar fue del 66% (IC del 95%: 52-78%). La prevalencia por región fue heterogénea, siendo el departamento del Amazonas donde se ubicó la prevalencia más alta (69%) y los Santanderes la más baja (28%). En los últimos 20 años, la prevalencia de helmintiasis ha disminuido del 64.66% en 1990-1995 al 22.09% en 2016-2020. Conclusión: La prevalencia de las IPIs es alta (>30%) en tres de las siete regiones de Colombia. Se recomienda la administración bianual masiva de antiparasitarios en niños en edad escolar en la región del Amazonas. Las políticas públicas destinadas a controlar las IPIs deben reforzarse. Futuros estudios de prevalencia deben incluir a los departamentos de Cesar, Guaviare, Vichada y Vaupés, ya que son departamentos donde la epidemiología de las IPIs es desconocida.

Abstract: Danger-associated molecular patterns (DAMPs) may be implicated in the pathophysiological pathways associated with an unfavorable outcome after acute brain injury (ABI). Differences in vCSF protein expression over time were evaluated using linear models and selected for functional network analysis using the PANTHER and STRING databases. The primary exposure of interest was the type of brain injury (traumatic vs. nontraumatic), and the primary outcome was the vCSF expression of DAMPs. Secondary exposures of interest included the occurrence of intracranial pressure ?20 or ? 30 mm Hg during the 5 days post- ABI, intensive care unit (ICU) mortality, and neurological outcome (assessed using the Glasgow Outcome Score) at 3 months post-ICU discharge. Secondary outcomes included associations of these exposures with the vCSF expression of DAMPs. A network of 6 DAMPs (DAMP_trauma; protein-protein interaction [PPI] P= 0.04) was differentially expressed in patients with ABI of traumatic origin compared with those with nontraumatic ABI. ABI patients with intracranial pressure ?30 mm Hg differentially expressed a set of 38 DAMPS (DAMP_ICP30; PPI P< 0.001). Proteins in DAMP_ICP30 are involved in cellular proteolysis, complement pathway activation, and post-translational modifications. Specific patterns of vCSF DAMP expression differentiated between traumatic and nontraumatic types of ABI and were associated with increased episodes of severe intracranial hypertension. Resumen: Los patrones moleculares asociados al peligro (DAMP) pueden estar implicados en las vías fisiopatológicas asociadas con un resultado desfavorable después de una lesión cerebral aguda (LCA). Las diferencias en la expresión proteíca vCSF a lo largo del tiempo se evaluaron utilizando modelos lineales y se seleccionaron para el análisis de redes funcionales utilizando las bases de datos PANTHER y STRING. La principal exposición de interés fue el tipo de lesión cerebral (traumática versus no traumática), y el resultado primario fue la expresión de DAMP en vCSF. Las exposiciones secundarias de interés incluyeron la aparición de presión intracraneal ?20 o ? 30 mm Hg durante los 5 días posteriores a la LCA, mortalidad en la unidad de cuidados intensivos (UCI) y resultado neurológico (evaluado mediante el Glasgow Outcome Score) 3 meses después del alta de la UCI. Una red de 6 DAMP (DAMP_trauma; interacción proteínaproteína [PPI] P = 0,04) se expresó diferencialmente en pacientes con LCA de origen traumático en comparación con aquellos con LCA no traumática. Los pacientes con ITB con presión intracraneal ?30 mm Hg expresaron diferencialmente un conjunto de 38 DAMPS (DAMP_ICP30; PPI P <0,001). Las proteínas en DAMP_ICP30 participan en la proteólisis celular, la activación de la vía del complemento y las modificaciones postraduccionales. Los patrones específicos de expresión de vCSF DAMP diferenciaron entre tipos de LCA traumática y no traumática y se asociaron con un aumento de episodios de hipertensión intracraneal severa.

Abstract: Objective: To evaluate and compare the mechanical properties, water sorption, water solubility, and degree of double bond conversion of three different commercially available threedimensional (3D) printing resins used for the fabrication of flexible occlusal splints. Methods: A digital printer was used to generate specimens from the evaluated splint materials (KeySplint Soft, IMPRIMO LC Splint flex, and V-Print splint comfort). The specimens were equally divided and tested either dry or after water storage at 37 ? C for 30 days. A three-point bending test was used to assess flexural strength, elastic modulus, and fracture toughness. A two-body wear test was performed using a dual-axis chewing simulator. Water sorption and water solubility were measured after 30 days. The degree of double bond conversion was determined by FTIR-spectrometry. All data for the evaluated properties were collected and statistically analyzed. Results: Both material and storage conditions had a significant effect on the flexural strength (P < 0.001), elastic modulus (P < 0.001), fracture toughness (P < 0.001), and wear (P < 0.001). The highest water sorption was noticed with IMPRIMO LC Splint flex (1.9 ± 0.0 %), while V-Print splint comfort displayed the lowest water solubility (0.2 ± 0.0 %). For the degree of conversion, it was statistically nonsignificant among the different materials (P = 0.087). Significance: Different flexible 3D-printed splints available in the market displayed variations in the evaluated properties and clinicians should consider these differences when choosing occlusal device materials. Among the tested flexible splint materials, KeySplint Soft had the greatest flexural strength, elastic modulus, fracture toughness, wear resistance, and degree of conversion. It also showed the lowest water sorption. Resumen: Objetivo: Evaluar y comparar las propiedades mecánicas, sorción de agua, solubilidad en agua y grado de conversión de doble enlace de tres resinas de impresión tridimensionales (3D) diferentes, disponibles comercialmente, utilizadas para la fabricación de férulas oclusales flexibles. Métodos: Se utilizó una impresora digital para generar muestras a partir de los materiales de férula evaluados (KeySplint Soft, IMPRIMO LC Splint flex y V-Print splint comfort). Las muestras se dividieron equitativamente y se probaron en seco o después del almacenamiento en agua a 37 ? C durante 30 días. Se utilizó una prueba de flexión de tres puntos para evaluar la resistencia a la flexión, la elasticidad módulo y tenacidad a la fractura. Se realizó una prueba de desgaste de dos cuerpos utilizando un simulador de masticación de doble eje. La sorción y la solubilidad en agua se midieron después de 30 días. El grado de conversión del doble enlace fue determinado por espectrometría FTIR. Todos los datos de las propiedades evaluadas fueron recopilados y analizados estadísticamente. Resultados: Tanto el material como las condiciones de almacenamiento tuvieron un efecto significativo sobre la resistencia a la flexión (P < 0,001), módulo de elasticidad (P <0,001), tenacidad a la fractura (P <0,001) y desgaste (P <0,001). La mayor sorción de agua fue notado con IMPRIMO LC Splint flex (1,9 ± 0,0 %), mientras que la férula V-Print comfort mostró la menor solubilidad al agua (0,2 ± 0,0 %). Para el grado de conversión, no hubo diferencia significativa estadísticamente entre los diferentes materiales (P = 0,087). Importancia: Las diferentes férulas flexibles impresas en 3D disponibles en el mercado mostraron variaciones en las propiedades evaluadas y los clínicos deben considerar estas diferencias al elegir los materiales para dispositivos oclusales. Entre los materiales de férula flexibles probados, KeySplint Soft tuvo la mayor resistencia a la flexión, módulo elástico, tenacidad, resistencia al desgaste y grado de conversión. También mostró la menor sorción de agua.

Abstract: The aim of this in vitro study was to evaluate the wear and surface hardness of nine materials for conventional manufacturing, subtractive milling, and 3D printing of occlusal splints, as well as to evaluate the differences in wear and surface hardness between rigid and flexible 3D-printed occlusal splint materials. Two-body wear and Vickers hardness tests were performed. The vertical wear depth and Vickers hardness values were statistically analyzed. Vertical wear depth and surface hardness values were statistically significant among the investigated materials (p<0.05). The lowest vertical wear depth was observed for the heat-cured resin (27.5±2.4 ?m), PMMA-based milled material (30.5±2.8 ?m), and autopolymerizing resin (36.7±6.3 ?m), with no statistical difference (p<0.05). Flexible 3D-printed and CAD-CAM milled polycarbonate-based splint materials displayed lower surface hardness and higher wear than the PMMA-based materials. PMMA-based splint materials displayed the most consistent surface hardness and wear resistance regardless of the manufacturing technology. Resumen: El objetivo de este estudio in vitro fue evaluar el desgaste y la dureza superficial de nueve materiales para la fabricación convencional, fresado sustractivo e impresión 3D de férulas oclusales, así como para evaluar las diferencias en el desgaste y la dureza de la superficie entre Materiales rígidos y flexibles para férulas oclusales impresas en 3D. Se realizaron pruebas de desgaste de dos cuerpos y dureza Vickers. Se analizaron estadísticamente los valores de profundidad y dureza Vickers. Los valores de profundidad de desgaste vertical y dureza superficial fueron estadísticamente significativa entre los materiales investigados (p<0,05). La profundidad de desgaste vertical más baja se observó para la resina termocurada (27,5 ± 2,4?m), material molido a base de PMMA (30,5±2,8 ?m) y resina autopolimerizable (36,7±6,3 ?m), sin diferencia estadística (p<0,05). Los materiales flexibles para férulas a base de policarbonato impresos en 3D y fresados con CAD-CAM mostraron una menor dureza superficial y un mayor desgaste que los materiales basados en PMMA. Los materiales para férulas a base de PMMA mostraron la dureza superficial y la resistencia al desgaste más consistentes independientemente de la tecnología de fabricación.

Abstract: Aim: the aim of this study was to compare the flexural strength and elastic modulus of three-dimensionally (3D) printed, conventional heat-cured, and high-impact implant-supported overdenture materials specimens. Materials and Methods: Thirty implant-supported overdenture materials specimens (bar-shaped, 65.0 × 10.2 × 5.1 ± 0.2 mm 3) with one central hole were fabricated using 3D-printed, heat-cured conventional, and high-impact denture base resins (n = 10/group). Autopolymerizing acrylic resin was used to attach titanium matrix housings to the central holes of the specimens. A three-point bending test was conducted using a universal testing machine and a model analog with a crosshead speed of 5 mm/min. The indicative flexural strength and elastic modulus were recorded. Data were statistically analyzed using analysis of variance (ANOVA) and the Tukey tests at ? = 0.05. Results: One-way ANOVA revealed a significant effect of denture base material on the flexural strength (p < 0.001) but not on the elastic modulus (p = 0.451) of the evaluated materials. The flexural strength of the 3D-printed specimens (95.99 ± 9.87 MPa) was significantly higher than the conventional (77.18 ± 9.69 MPa; p < 0.001) and high-impact ones (82.74 ± 7.73 MPa; p = 0.002). Conclusions: The maximum flexural strength was observed in the 3D-printed implant- supported overdenture material specimens, which might indicate their suitability as an alternative to the conventionally fabricated ones. Flexural strength and elastic modulus of conventional and high-impact heat-cured implant-supported overdenture materials specimens were comparable. Resumen: Objetivo: el objetivo de este estudio fue comparar la resistencia a la flexión y el módulo elástico de impresos en tres dimensiones (3D), curados con calor convencionales y soportados por implantes de alto impacto Muestras de materiales para sobredentaduras. Materiales y métodos: Treinta sobredentaduras implantosoportadas. Se fabricaron muestras de materiales (en forma de barra, 65,0 × 10,2 × 5,1 ± 0,2 mm 3) con un orificio central. utilizando resinas de base para prótesis dentales impresas en 3D, termocuradas convencionales y de alto impacto (n = 10/grupo). Se utilizó resina acrílica autopolimerizante para unir carcasas de matriz de titanio a los orificios centrales de los ejemplares. Se realizó una prueba de flexión de tres puntos utilizando una máquina de prueba universal y un modelo analógico con una velocidad de cruceta de 5 mm/min. La resistencia a la flexión y el elástico indicativos. Se registraron los módulos. Los datos se analizaron estadísticamente mediante análisis de varianza (ANOVA) y las pruebas de Tukey en ? = 0,05. Resultados: ANOVA unidireccional reveló un efecto significativo de la base de la dentadura postiza material en la resistencia a la flexión (p < 0,001) pero no en el módulo elástico (p = 0,451) del evaluando materiales. La resistencia a la flexión de las muestras impresas en 3D (95,99 ± 9,87 MPa) fue significativamente superiores a los convencionales (77,18 ± 9,69 MPa; p < 0,001) y a los de alto impacto (82,74 ± 7,73 MPa; p = 0,002). Conclusiones: La máxima resistencia a la flexión se observó en el implante impreso en 3D. Muestras de material para sobredentaduras soportadas, que podrían indicar su idoneidad como alternativa. A los fabricados convencionalmente. Resistencia a la flexión y módulo elástico de convencionales y Las muestras de materiales para sobredentaduras implantosoportados termoendurecidos de alto impacto fueron comparables.

Abstract: The aim of this work was to investigate the effect of two post-curing methods on the mechanical properties of a 3D-printed denture base material. Additionally, to compare the mechanical properties of that 3D-printed material with those of conventional autopolymerizing and a heat-cured denture base material. A resin for 3D-printing denture base (Imprimo ®), a heat-polymerizing acrylic resin (Paladon ® 65), and an autopolymerizing acrylic resin (Palapress ®) were investigated. Flexural strength, elastic modulus, fracture toughness, work of fracture, water sorption, and water solubility were evaluated. The 3D-printed test specimens were post-cured using two different units (Imprimo Cure ® and Form Cure ®). The tests were carried out after both dry and 30 days water storage. Data were collected and statistically analyzed. Resin type had a significant effect on the flexural strength, elastic modulus, fracture toughness, and work of fracture (p < 0.001). The flexural strength and elastic modulus for the heat-cured polymer were significantly the highest among all investigated groups regardless of the storage condition (p < 0.001). The fracture toughness and work of fracture of the 3Dprinted material were significantly the lowest (p < 0.001). The heat-cured polymer had the lowest significant water solubility (p < 0.001). The post-curing method had an impact on the flexural strength of the investigated 3D-printed denture base material. The flexural strength, elastic modulus, fracture toughness, work of fracture of the 3D-printed material were inferior to those of the heat-cured one. Increased post-curing temperature may enhance the flexural properties of resin monomers used for 3D-printing dental appliances. Resumen: El objetivo de este trabajo fue investigar el efecto de dos métodos de poscurado en la Propiedades mecánicas de un material base para prótesis dental impreso en 3D. Además, para comparar la mecánica propiedades de ese material impreso en 3D con las de la autopolimerización convencional y un curado por calor material base de la dentadura postiza. Una resina para la impresión 3D de bases de prótesis dentales (Imprimo ®), un acrílico termopolimerizable Se investigaron una resina (Paladon ® 65) y una resina acrílica autopolimerizable (Palapress ®). Flexión Resistencia, módulo elástico, tenacidad a la fractura, trabajo de fractura, sorción de agua y solubilidad en agua. fueron evaluados. Las muestras de prueba impresas en 3D se curaron posteriormente utilizando dos unidades diferentes (Imprimo Cure® y Form Cure®). Las pruebas se llevaron a cabo después de un almacenamiento en seco y durante 30 días en agua. Datos fueron recolectados y analizados estadísticamente. El tipo de resina tuvo un efecto significativo sobre la resistencia a la flexión, módulo elástico, tenacidad a la fractura y trabajo de fractura (p < 0,001). La resistencia a la flexión y El módulo elástico para el polímero curado con calor fue significativamente el más alto entre todos los investigados. grupos independientemente de la condición de almacenamiento (p < 0,001). La tenacidad a la fractura y el trabajo de fractura. del material impreso en 3D fueron significativamente los más bajos (p <0,001). El polímero curado por calor tenía la solubilidad en agua significativa más baja (p < 0,001). El método de poscurado tuvo un impacto en la Resistencia a la flexión del material de base de la dentadura postiza impreso en 3D investigado. La resistencia a la flexión, elástica. El módulo, la tenacidad a la fractura y el trabajo de fractura del material impreso en 3D fueron inferiores a los del curado con calor. El aumento de la temperatura de poscurado puede mejorar las propiedades de flexión de la resina monómeros utilizados para aparatos dentales de impresión 3D.