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An astrocytic basis of caloric restriction action on the brain plasticity

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Año de publicación 2019
Idioma Inglés
Publicado por BioRxiv preprint

Descripción: Abstract: One month of calorically restricted diet (CR) induced morphological plasticity of astrocytes in the stratum (str.) radiatum of hippocampal CA1 in three-months old mice: the volume fraction of distal perisynaptic astrocytic processes increased whereas the number of gap-junction coupled astrocytes decreased. The uncoupling was not associated with a decrease in the expression of connexin 43. Uncoupling and morphological remodeling affected spontaneous Ca2+ activity in the astrocytic network: Ca2+ events became longer, whereas their spread was reduced. The change in the pattern of astrocytic Ca2+ activity may increase the spatial resolution of the information encoding in the astroglial network. Consistent with expanded synaptic enwrapping by the astroglial processes, the spillover of synaptically released K+ and glutamate was diminished after CR. However, no significant changes in the expression of astrocytic glutamate transporter (GLT-1/EAAT2) were observed, although the level of glutamine synthetase was decreased. Glutamate uptake is known to regulate the synaptic plasticity. Indeed, the magnitude of long-term potentiation (LTP) in the glutamatergic CA3-CA1 synapses was significantly enhanced after CR. Our findings highlight an astroglial basis for improved learning and memory reported in various species subjected to CR.
Citación recomendada (normas APA)
: Alex Fernell; Popov Plata Ayala, "An astrocytic basis of caloric restriction action on the brain plasticity", Colombia:BioRxiv preprint, 2019. Consultado en línea en la Biblioteca Digital de Bogotá (https://www.bibliotecadigitaldebogota.gov.co/resources/3711573/), el día 2025-05-07.

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Fuente Biblioteca Virtual Banco de la República
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Año de publicación 2019
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Cobertura Colombia

An astrocytic basis of caloric restriction action on the brain plasticity

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