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Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance

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Autor
Año de publicación 2022
Idioma Inglés
Publicado por Trends in Microbiology

Descripción: Abstract: The cell envelope is essential for the survival and adaptation of bacteria. Bacterial membrane proteins include the major porins that mediate the influx of nutrients and several classes of antimicrobial drugs. Consequently, membrane remodelling is closely linked to antimicrobial resistance (AMR). Knowledge of bacterial membrane protein biogenesis and turnover underpins our understanding of bacterial membrane remodelling and the consequences that this process has in the evolution of AMR phenotypes. At the population level, the evolution of phenotypes is a reversible process, and we can use these insights to deploy evolutionary principles to resensitize bacteria to existing antimicrobial drugs. In our opinion, fundamental knowledge is opening a new way of thinking towards sustainable solutions to the mounting crisis in AMR. Here we discuss what is known about outer-membrane remodelling in bacteria and how the process could be targeted as a means to restore sensitivity to antimicrobial drugs. Bacteriophages are highlighted as a powerful means to exert this control over membrane remodelling but they require careful selection so as to reverse, and not exacerbate AMR phenotypes.
Citación recomendada (normas APA)
: Natalia Carolina; Lithgow Rosas Bastidas, "Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance", Colombia:Trends in Microbiology, 2022. Consultado en línea en la Biblioteca Digital de Bogotá (https://www.bibliotecadigitaldebogota.gov.co/resources/3711809/), el día 2025-05-09.

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Temas
- Otros
- Medicina
Derechos de uso Derechos reservados
Fuente Biblioteca Virtual Banco de la República
Términos y condiciones de uso Más información aquí
Año de publicación 2022
Formato PDF
Cobertura Colombia

Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance

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Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance

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