Artículos

Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation

CONTENIDO DE LIBRE ACCESO

Este contenido es de libre acceso. Solo haz clic en el siguiente botón.

Autor
Año de publicación 2017
Idioma Inglés
Publicado por Applied Surface Science; Vol. 393

Descripción: Biomimetic surface modification with peptides that have specific cell-binding moieties is a promising approach to improve endothelialization of metal-based stents. In this study, we functionalized CoCr surfaces with RGDS, REDV, YIGSR peptides and their combinations to promote endothelial cells (ECs) adhesion and proliferation. An extensive characterization of the functionalized surfaces was performed by XPS analysis, surface charge and quartz crystal microbalance with dissipation monitoring (QCM-D), which demonstrated the successful immobilization of the peptides to the surface. Cell studies demonstrated that the covalent functionalization of CoCr surfaces with an equimolar combination of RGDS and YIGSR represents the most powerful strategy to enhance the early stages of ECs adhesion and proliferation, indicating a positive synergistic effect between the two peptide motifs. Although these peptide sequences slightly increased smooth muscle cells (SMCs) adhesion, these values were ten times lower than those observed for ECs. The combination of RGDS with the REDV sequence did not show synergistic effects in promoting the adhesion or proliferation of ECs. The strategy presented in this study holds great potential to overcome clinical limitations of current metal stents by enhancing their capacity to support surface endothelialization.
Citación recomendada (normas APA)
: María Isabel; Mas-Moruno Castellanos Arboleda, "Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation", -:Applied Surface Science; Vol. 393, 2017. Consultado en línea en la Biblioteca Digital de Bogotá (https://www.bibliotecadigitaldebogota.gov.co/resources/2084789/), el día 2025-05-12.

Información adicional

Temas
- Otros
Derechos de uso Derechos reservados
Fuente Biblioteca Virtual Banco de la República
Términos y condiciones de uso Más información aquí
Año de publicación 2017
Formato PDF

Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation

Información adicional

Mis colecciones

¿Eliminar esta reseña?