Tesis de medicina de Rafael C. del Valle, en la que realiza un estudio crítico apoyado en observaciones personales sobre las ventajas e inconvenientes del atoxil , que tiende a restringir y precisar su empleo en las afecciones sifilíticas.

Con el estudio de la presente cartilla, usted logrará los conocimientos al igual que la habilidad y destreza en el manejo de situaciones de emergencia por problemas respiratorios, con el fin de poder auxiliar al trabajador en forma oportuna.

Hydrogenosomes and mitosomes represent remarkable mitochondrial adaptations in the anaerobic parasitic protists such as Trichomonas vaginalis and Giardia intestinalis, respectively. In order to provide a tool to study these organelles in the live cells, the HaloTag was fused to G. intestinalis IscU and T. vaginalis frataxin and expressed in the mitosomes and hydrogenosomes, respectively.The incubation of the parasites with the fluorescent Halo-ligand resulted in highly specific organellar labeling, allowing live imaging of the organelles. With the array of available ligands the HaloTag technology offers a new tool to study the dynamics of mitochondria-related compartments as well as other cellular components in these intriguing unicellular eukaryotes.

To improve cardiovascular implant success, metal-based stents are designated to modulate endothelial cells adhesion and migration in order to prevent restenosis and late thrombosis diseases. Biomimetic coatings with extra-cellular matrix adhesive biomolecules onto stents surfaces are a strategy to recover a healthy endothelium.However, the appropriate bioactive sequences to selective promote growth of endothelium and the biomolecules surface immobilization strategy remains to be elucidated. In this study, biofunctionalization of cobalt chromium, CoCr, alloy surfaces with elastin-like recombinamers, ELR, genetically modified with an REDV sequence, was performed to enhance metal surfaces endothelialization.Moreover, physical adsorption and covalent bonding were used as biomolecules binding strategies onto CoCr alloy. Surfaces were activated with plasma and etched with sodium hydroxide previous to silanization with 3-chloropropyltriethoxysilane and functionalized with the ELR. CoCr alloy surfaces were successfully biofunctionalized and the use of an ELR with an REDV sequence, allows conferring bioactivity to the biomaterials surface, demonstrating a higher cell adhesion and spreading of HUVEC cells on the different CoCr surfaces.This effect is emphasized as increases the amount of immobilized biomolecules and directly related to the immobilization technique, covalent bonding, and the increase of surface charge electronegativity. Our strategy of REDV elastin-like recombinamers immobilization onto CoCr alloy surfaces via covalent bonding through organosilanes provides a bioactive surface that promotes endothelial cell adhesion and spreading.

Background: Physicians face intrinsic tensions when practicing medicine; therefore, extrinsic factors that could affect distress, such as payment methods, need to be assessed. The study objectives were to: compare levels of distress by payment method, identify factors predicting distress in a two-level regression model, and explore interactions between predictors of distress and payment method.Methods: A cross-sectional study was conducted among physicians in the Saskatoon Health Region, Saskatchewan. Physicians completed a pre-tested questionnaire about their distress. Analysis of variance was used to compare distress levels of physicians paid by fee-for-service (FFS), alternative payment plans (APPs), and blended methods. A mixed linear regression model was built to predict distress with geographical area of practice as the random component. Demographics, workload, complexity of patients, payment method, career satisfaction, and practice profile were the independent variables. The interactions between payment method and predictors of daily distress were evaluated.Results: A total of 382 physicians participated. Response bias was tested and found to be negligible. In the multivariable analysis, payment method was a predictor of distress which interacted with the proportion of complex cases. Lower levels of distress were found among physicians who had more than 75% of patients with complex conditions and were paid by APPs, compared to those paid by FFS and blended methods. Career satisfaction was found to be an important predictor. Nine percent of the outcome variation was explained by geographic area of practice. Conclusions: Payment method is a predictor of distress when adjusting by confounders, interacting with proportion of complex cases. APPs may promote provision of care for patients with complex conditions. Career satisfaction can be considered a protective indicator of distress. Practice environment influences distress experienced by physicians.

Background and purpose: Chloroquine (CLQ), an antimalarial drug, has a lysosomotropic effect associated with increased radiationsensibility, which is mediated by the leakage of hydrolytic enzymes, increased apoptosis, autophagy and increased oxidative stress in vitro. In this phase II study, we evaluated the efficacy and safety of radiosensibilization using CLQ concomitant with 30 Gray (Gy) of whole-brain irradiation (WBI) to treat patients with brain metastases (BM) from solid tumors.Methods: Seventy-three eligible patients were randomized. Thirty-nine patients received WBI (30 Gy in 10 fractions over 2 weeks) concomitant with 150 mg of CLQ for 4 weeks (the CLQ arm). Thirty-four patients received the same schedule of WBI concomitant with a placebo for 4 weeks (the control arm). All the patients were evaluated for quality of life (QoL) using the EORTC Quality of Life (QoL) Questionnaire (EORTC QLQ-C30) (Mexican version) beforebeginning radiotherapy and one month later.Results: The overall response rate (ORR) was 54% for the CLQ arm and 55% for the control arm (p=0.92). The progression-free survival of brain metastases (BMPFS) rates at one year were 83.9% (95% CI 69.4-98.4) for the CLQ arm and 55.1% (95% CI 33.6-77.6) for the control arm. Treatment with CLQ was independently associated with increased BMPFS (RR 0.31,95% CI [0.1-0.9], p=0.046).The only factor that was independently associated with increased overall survival (OS) was the presence of< 4 brain metastases (RR 1.9, 95% CI [1.12-3.3], p=0.017). WBI was associated with improvements in cognitive and emotional function but also with worsened nausea in both patients groups. No differences in QoL or toxicity were found between the study arms.Conclusion: Treatment with CLQ plus WBI improved the control of BM (compared with the control arm) with no increase in toxicity; however, CLQ did not improve the RR or OS. A phase III clinical trial is warranted to confirm these findings.

Abstract:OBJECTIVE:To study the severity of symptoms and estimate the prevalence of oral mucosal lesions in a non-referral adult Swedish population, as registered by general dental practitioners. This study also aims to evaluate the possibility of dental practitioners collecting large quantities of reliable and accurate clinical data on oral mucosal lesions.STUDY DESIGN:Data from 6,448 adult Swedish patients were collected by general dental practitioners using a standardized registration method. A correlation analysis between a group with oral mucosal lesions and a control group, with no oral mucosal lesions, was performed for various parameters such as symptoms from the oral mucosa, systemic diseases, medication, allergy history, tobacco habits and the patient's own assessment of their general health. In addition, clinical photos were taken of all oral mucosal lesions in order to determine the degree of agreement between the diagnoses made by general dental practitioners and those made by oral medicine specialists.RESULTS:A total of 950 patients (14.7%) presented with some type of oral mucosal lesion and of these, 141 patients (14.8%) reported subjective symptoms. On a visual analogue scale, 43 patients (4.5%) scored their symptoms <30, 65 patients (6.8%) scored their symptoms ?30, and 28 patients (2.6%) scored their symptoms ?60. The most debilitating condition was aphthous stomatitis and the most common oral mucosal lesion was snuff dipper's lesion (4.8%), followed by lichenoid lesions (2.4%) and geographic tongue (2.2%). There was agreement between the oral medicine specialists and the general practitioners over the diagnosis of oral mucosal lesions on the basis of a clinical photograph in 85% of the cases (n=803).CONCLUSIONS:Nearly 15% of the patients with oral mucosal lesions reported symptoms. General practitioners could contribute significantly to the collection of large quantities of reliable and accurate clinical data, although there is a risk that the prevalence of oral mucosal lesions may be underestimated."Resumen:OBJETIVO: Estudiar la severidad de los síntomas y estimar la prevalencia de lesiones de la mucosa oral en una población de Suecia no referida, y registrada por odontólogos generales. Este estudio también tiene como objetivo evaluar la posibilidad de que odontólogos generales recolecten de forma confiable y precisa grandes cantidades de datos clínicos sobre lesiones de la mucosa oral. DISEÑO DEL ESTUDIO: Datos de 6.448 pacientes adultos suecos fueron recolectados por odontólogos generales usando un método estandarizado de registro. Un análisis de correlación entre un grupo de pacientes con lesiones de la mucosa oral y un grupo control, sin lesiones de la mucosa oral, fue realizado para varios parámetros como síntomas en la mucosa oral, enfermedades sistémicas, medicamentos, alergias, tabaquismo, y la percepción del propio paciente sobre su estado de salud. Además, se tomaron fotos clínicas de todas las lesiones de la mucosa oral con el fin de determinar el grado de concordancia entre los diagnósticos realizados por los odontólogos generales y los especialistas en medicina oral. RESULTADOS: Un total de 950 pacientes (14.7%) presentó algún tipo de lesión de la mucosa oral, y de estos, 141 pacientes (14.8%) reportaron síntomas subjetivos. En una escala analógica visual, 43 pacientes (4.5%) calificaron sus síntomas <30, 65 pacientes (6.8%) calificaron sus síntomas ≥30, y 28 pacientes (2.6%) calificaron sus síntomas ≥60. La condición más debilitante fue la stomatitis aftosa y la lesión más común fue la lesión causada por el tabaco húmedo (4.8%), seguida por reacciones liquenoides (2.4%) y lengua geográfica (2.2%). Basado en las fotografías clínicas, hubo una concordancia en el diagnóstico de lesiones de la mucosa oral entre los especialistas en medicina oral y los odontólogos generales en el 85% de los casos (n=803). CONCLUSION: Aproximadamente el 15% de los pacientes con lesiones de la mucosa oral reportaron síntomas. Los odontólogos generales pueden contribuir significativamente en la recolección confiable y precisa de grandes cantidades de datos clínicos, aunque existe un riego de que la prevalencia de lesiones de la mucosa oral pueda ser subestimada."

Resumen:Antecedentes y objetivo: Se llevó a cabo una revisión de la literatura que evidencia problemas y necesidades en la diada paciente – cuidador familiar en cuidados paliativos durante el proceso de transición entre el hospital y el hogar. Estas necesidades tienen relación con: los conocimientos relacionados con la enfermedad, los sentimientos del cuidador y del paciente al alta, la comunicación efectiva, la educación para el cuidado a domicilio, el apoyo a la diada en el domicilio y la sobrecarga del cuidado - soporte social para el cuidador. La escasa evidencia sobre las experiencias en el proceso de transición hospital-hogar, así como de estudios en el ámbito latinoamericano, llevan a plantear una propuesta de investigación con el objetivo de describir la experiencia de la diada paciente – cuidador familiar en cuidado paliativo durante el proceso de transición entre el hospital y el hogar, en el contexto colombiano.Materiales y métodos: Esta propuesta se llevará a cabo utilizando metodología cualitativa con abordaje de teoría fundamentada. Los informantes del estudio serán pacientes y cuidadores familiares en cuidados paliativos en una institución sanitaria de Bogotá-Colombia. Para la recogida de datos, se utilizará la técnica de la entrevista familiar semiestructurada, que se realizará a las diadas en el hospital y posteriormente en el domicilio. El análisis de los datos se hará a través del método comparativo constante.Implicaciones prácticas: Conocer las experiencias de la diada al alta hospitalaria, saber los retos a los que se enfrentan en el domicilio y las necesidades que tienen durante este proceso, ayudaría a mejorar la atención a estas familias que requieren de cuidados paliativos. Abstract :BACKGROUND AND OBJECTIVE: We carried out a review of the literature that evidences problems and needs in the patient - caregiver family in palliative care during the transition process between the hospital and the home. These needs are related to: knowledge related to illness, feelings of caregiver and patient on discharge, effective communication, education for home care, home support and care overload - support For the caregiver. The lack of evidence on experiences in the transition process from home to hospital, as well as from studies in the Latin American context, lead to a research proposal with the objective of describing the experience of the patient-caregiver family in palliative care during the Process of transition between the hospital and the home, in the Colombian context.Materials and methods: This proposal will be carried out using qualitative methodology with a grounded theory approach. The informants of the study will be patients and family caregivers in palliative care at a health institution in Bogota-Colombia. For the collection of data, the semi-structured family interview technique will be used, which will be done at the dyads in the hospital and later at the home. The analysis of the data will be done through the constant comparative method.Practical implications: Knowing the experiences of the hospital discharge, knowing the challenges they face at home and the needs they have during this process, would help to improve care for these families that require palliative care.

Resumo: Neste estudo analisam-se o câncer de colo uterino como problema social e as contribuições da enfermagem na realização de testes para detectá-lo precocemente. Metodologicamente se fundamenta na epidemiologia descritiva e na revisão sistemática. Os resultados são apresentados na forma de artigos. No primeiro, Câncer de colo do útero: um problema social mundial, é analisado o câncer de colo de útero como problema social. Estudo transversal, com dados populacionais coletados na base de dados Globocan-2008. Foram utilizados dados das Taxas de Incidência e das Taxas de Mortalidade por 100.000 mulheres e percentuais de risco acumulado de incidência e mortalidade antes dos 75 anos pela doença nas regiões desenvolvidas e em desenvolvimento do mundo.Na análise são aplicadas as classificações da Organização das Nações Unidas (ONU) de desenvolvimento dos países ou regiões com base em projeções sociais e demográficas e os níveis de classificação das Taxas de Incidência e de Mortalidade do International Agency for Research on Cancer (IARC). O segundo artigo, Câncer de colo do útero: mortalidade em Santa Catarina – Brasil, 2000 a 2009, foi desenvolvido com base nos dados dos óbitos de mulheres por câncer de colo do útero, inclusive os de porção não especificada, ocorridos em Santa Catarina no período de 2000 a 2009, obtidos no Sistema de Informação de Mortalidade (SIM) do Ministério da Saúde e do Instituto Brasileiro de Geografia e Estatística (IBGE). Observou-se que as taxas de mortalidade mais elevadas incidiram em mulheres a partir dos trinta anos e que o câncer de colo uterino ainda não foi controlado.No terceiro artigo, A enfermagem na detecção precoce do câncer de colo uterino: revisão sistemática, são analisadas as contribuições da Enfermagem para a título e resumo foram pré-selecionados 174, os quais foram lidos integralmente, resultando na seleção de 10 artigos. O pessoal de enfermagem atuou como participante em nove pesquisas e como pesquisador em três pesquisas. A maioria dos artigos foi classificada com o nível de evidência 3B segundo a classificação Oxford; somente um obteve nível 4.Há contribuição de Enfermagem na realização de exames para detecção precoce do câncer de colo uterino, apesar do nível de evidência com que foram classificados os artigos. Conclui-se que o impacto da doença nas mulheres, nas suas famílias e nas sociedades demanda modificações no quadro das iniquidades sociais com adoção de estratégias intersetoriais que também facilitem o acesso aos serviços de saúde. O cuidado de enfermagem é uma estratégia para atender a responsabilidade social com as mulheres, as famílias e as sociedades e contribuir na detecção precoce da doença, favorecendo a qualidade de vida de milhares de mulheres. Resumen: En este estudio se analizan el cáncer de cuello uterino como problema social y las contribuciones de la enfermería en la realización de pruebas para detectarlo precozmente. Metodológicamente se fundamenta en la epidemiologia descriptiva y en la revisión sistemática. Los resultados son presentados en la forma de artículos. En el primer, El cáncer de cuello de útero: un problema social mundial, es analizado el cáncer de cuello de útero como problema social. Estudio transversal, con datos poblacionales recolectados en la base de datos Globocan-2008. Fueron utilizados datos de las Tasas de Incidencia y de las Tasas de Mortalidad por 100.000 mujeres y porcentajes de riesgo acumulado de incidencia y mortalidad antes de los 75 años por cáncer de cuello uterino en las regiones desarrolladas y en desarrollo.En el análisis son aplicadas las clasificaciones de la Organización de las Naciones Unidas (ONU) de desarrollo de los países o regiones con base en proyecciones sociales y demográficas y los niveles de clasificación de las Tasas de Incidencia y de Mortalidad de la International Agency for Research on Cancer (IARC). El segundo artículo, Cáncer de cuello de útero: mortalidad en Santa Catarina – Brasil, 2000 a 2009, fue desarrollado con base en los datos de las muertes de mujeres por cáncer de cuello de útero, inclusive los de porción no específica, ocurridos en Santa Catarina en el período de 2000 a 2009, obtenidos en el Sistema de Información de Mortalidad (SIM) del Ministerio de Salud y del Instituto Brasileiro de Geografía y Estadística (IBGE).Se observó que las tasas de mortalidad elevadas incidieron en mujeres a partir de los treinta años y que el cáncer de cuello uterino todavía no fue controlado. En el tercer artículo, Contribuciones de la enfermería en la detección precoz del cáncer de cuello de útero: revisión sistemática, son analizadas las contribuciones de la enfermería para la detección precoz de esa neoplasia. Revisión sistemática con artículos recuperados en el año de 2010 en las bases de datos MEDLINE, Cochrane, CINHAHL y LILACS. De los 3091 artículos identificados, después de la lectura del título y resumen fueron preseleccionados 174, los cuales fueron leídos integralmente, resultando en la selección de 10 artículos.El personal de enfermería actuó como participante en nueve investigaciones y como investigador en tres investigaciones. El nivel de evidencia 3B, en la clasificación Oxford, ocurrió en la mayoría de los artículos; solamente uno obtuvo nivel 4. Hay contribuciones de enfermería en la realización de exámenes para detección precoz del cáncer de cuello uterino, a pesar del nivel de evidencia en el que fueron clasificados los artículos. Se concluye que el impacto de la enfermedad en las mujeres, en las familias y en las sociedades demanda modificaciones en el cuadro de las inequidades sociales con adopción de estrategias intersectoriales que también faciliten el acceso a los servicios de salud. El cuidado de enfermería es una estrategia para atender la responsabilidad social con las mujeres, las familias y las sociedades y contribuir en la detección precoz de la enfermad, favoreciendo la calidad de vida de millares de mujeres. Abstract: In this study cervix cancer is analyzed as a social problem and the contribution of nursing in applying screening tests for the early detection of cervical cancer. Methodology is based on descriptive epidemiology and a systematic review. The results were presented like articles. In the first article, Cervical cancer: a social problem, and analyzing cervical cancer as a social problem. Cross sectional Study, with population data collected using the Globocan-2008 databases. Data from incidence and mortality rates per 100.000 women, and accumulated risk rates of cervical cancer incidence and mortality before the age of 75 in developed and developing regions of the world were used.In the analysis, the United Nations Organization classifications of countries or regions development based on social and demographic projections and the levels of classification of the incidence and mortality rates of the International Agency for Research on Cancer (IARC) are applied. The second article, Cervical Cancer: Mortality in Santa Catarina – Brazil, 2000 to 2009, obtained from the Information Mortality System (SIM) of the Ministry of Health and the Brazilian Institute of Geography and Statistics (IBGE). It was observed that the Mortality rate was higher in women in their early thirties and in whom the cervical cancer was not yet controlled.In the third article, Contributions of Nursing in the early detection of cervical cancer: systematic review. The contributions of nursing for the early detection of the disease were analyzed. Systematic review with articles recovered in the year of 2010 from MEDLINE, Cochrane, CINAHL and LILACS databases. After reading the titles and abstracts of the articles, from 3091 identified, 174 were pre-selected and read exhaustively resulting in the selection of 10 articles. The nursing staff participated in nine of the researches and in three of them they participated as researchers. Most of the articles had a level of evidence 3B, in the Oxford classification; only one of them had a level 4.There are also nursing contributions in the application of tests for the early detection of cervical cancer despite the level of evidence in which the articles were classified. It is concluded that the impact of the disease in women, their families and the society demand modifications in the role of social inequities with the adoption of inter-sector strategies that also facilitate the access to health services. Nursing care is a strategy to attend the social responsibility with women, their families and the society and contribute in the early detection of diseases, favoring the quality of life of millions of women.

Trabajo de grado de Antonio Gómez para obtener el título de Doctor y Cirujano de la Universidad Nacional, en 1922. En la primera parte se hace una recopilación sobre las investigaciones en torno al sarampión y lo que a la fecha se sabía de la enfermedad. En la segunda, se habla de la epidemia de sarampión en Bogotá de 1914 y la forma como fue fue atendida por parte del personal médico de la ciudad.