Abstract: Background: Seasonal Influenza is considered to be a cyclic and ordered sequence of values, influenced by external factors that can be predicted and used to detect disease outbreaks and monitoring. In machine learning, the key challenges that limit these analyses are in model explainability and limitations associated with ecological bias. Aim: Determine the best environmental variable selection method to predict Seasonal Influenza in Norway, using an environmental medicine approach combined with machine learning techniques. Methods: This is a quasi-experimental study that compares three approaches (non-variable selection, isolate component, and multipollutant mixture), represented in five methods (univariable, bivariable, multivariable AME, multivariable PCA, multivariable LDA). Per method, the best co-variable combination will be performed, following the internal rules of each method. The best covariable combination is the result of three components: variable selection, validation data set and lag. The first one involves 13 environmental variables (temperature, relative humidity, specific humidity, air pressure, wind speed, precipitation, CO, NO, NO2, O3, PM10, PM2,5 and SO2); second one compares a test dataset compiled from the data from 2019, last year (2018) and a synthetic environmental (avg. 2013-2018) data set in the validation process; and the third one compares a combination of lag from 0 to 12. All the predictions are made using ARIMA algorithm. The evaluation is given in terms of MAE, MSE, RMSE, OR. The training set is from 2 Jun 2013 (week 22/2013) to 28 May 2018 (week 21/2018), and test set is from (week 22/2018) to (week 21/2019) with a window of predictions of 52 weeks. Results: The increment of dimensionality in the environmental variable selection introduce different noise levels and optimize the prediction. Considerations that impact the explainability, usability, ecological bias and performance will be described. Conclusion: The increment of dimensionality in the variable selection has a better impact on performance than using complex algorithms.

Abstract: Biological and physiological changes in response to stress are crucial to achieving adaption to environmental constraints. Typical stress responses activate the sympathetic nervous system and the hypothalamic-pituitary-adrenal cortical axis, which aim to maintain homeostasis in response to demands and influence various biological responses at neuroendocrine, cellular, and immune levels. In particular, there is compelling evidence showing the devastating effects of high-stress levels on immune responses and brain functionality. In that sense, data suggest that a sustained stress-physiological response predicts decreases in immunity and leads to allostatic load, the wear, and tear of biological systems. Similarly, in cancer research, chronic stress levels have been reported to impair the bodysurveillance systems and be related to cancer incidence, progression, and mortality. Despite the evidence demonstrating the associations between stress and cancer, there are limited data on whether lifetime stress exposure relates to clinical indicators of cancer aggressiveness. Considering the evidence showing the adverse effects of prolonged stress exposure on cancer disease, this thesis aimed to explore the relationship between lifetime stress exposure and the clinical characteristics of tumor-aggressiveness in a cohort of patients affected with triple-negative breast cancer (TNBC). Likewise, as research has shown that coping responses moderate the stress-physiological response, we aimed to investigate the role of coping responses in moderating the association between tumor aggressiveness and lifetime stress exposure. According to the scientific literature, high-stress levels would increase physiological arousal and allostatic load favoring a debilitated immune system. Thus, we hypothesized finding positive associations between lifetime stress exposure and tumor-aggressiveness. In the same line, we suspected that adaptative coping styles would be negatively related to tumoraggressiveness. The participants of this study were 29 women diagnosed with TNBC who were treated in the University Hospital for Gynecology Pius-Hospital (Oldenburg, Germany). Correlation and moderation regression analyses with the use of composite scores were conducted. Overall, we could not demonstrate significant associations between lifetime stress exposure and coping responses on the clinical indicators of tumor aggressiveness in this cohort of patients. Possible explanations for these results are discussed, and suggestions for future research are provided. This study was the first to investigate the effect of lifetime stress exposure and coping response on the aggressive tumor characteristics of TNBC. We provided a deep theoretical framework to understand the interplay between biological and psychological aspects of cancer disease, and we hope that our recommendations may serve as a base for upcoming studies.

El único libro que te cuenta todo lo que necesitas saber sobre tu suelo pélvico en cada etapa de tu vida.Esta es la primera guía completa que nos presenta todas las disfunciones más comunes del suelo pélvico y cómo puede éste entrenarse y tratarse a sí mismo como parte de una rutina diaria. Jane Simpson sostiene la necesidad de celebrar la maravilla de nuestros músculos del suelo pélvico. ¿Alguna vez te has reído tanto que has llegado a mojarte? ¿Te has encontrado cruzando las piernas más de una vez en busca de un baño? ¿Te levantas por la noche para ir al baño más de una vez? Jane te muestra cómo incorporar los ejercicios del suelo pélvico como parte de tu rutina diaria para así prevenir problemas en un futuro y para curar los problemas existentes ahora.Un libro que te ayudará a tratar problemas tan comunes como la incontinencia, la vejiga hiperactiva y el prolapso, a ponerte en forma nuevamente después del embarazo y a disfrutar de una vida sexual saludable en cada etapa de tu vida.

La hipertensión arterial es un problema de salud pública en el mundo, constituye un factor importante en el 35% de los eventos cardiovasculares ateroscleróticos y hasta el 49% en los casos de falla cardíaca; además, está involucrada en el incremento de la tasa de eventos cerebrovasculares y, después de la diabetes mellitus, es la causa más frecuente de enfermedad renal crónica. La enfermedad cobra mayor importancia cuando las cifras de presión arterial no solo están relacionadas con aumento de la mortalidad, sino con años de vida perdidos ajustados por discapacidad

Colección Saberes Cotidianos. Número dedicado al conocimiento de la medicina tradicional china y los meridianos de acupuntura.

Un libro necesario, urgente, en medio del pandemónium de intereses y voces supuestamente expertas.A propósito de la pandemia, el presente texto nos exhorta a reflexionar sobre las repercusiones de esta en la economía, la sociedad y la salud; sobre el papel de las teorías conspiranoicas y negacionistas; sobre cómo se están cuestionando nuestros sistemas sanitarios públicos, qué limitaciones tienen y cómo se ha reaccionado y se está reaccionando a nivel mundial y, por supuesto, en España, así como a pensar los cambios que previsiblemente se producirán o deberían producirse en nuestros modelos sanitarios.

Abstract: The aim of this work was to investigate the effect of two post-curing methods on the mechanical properties of a 3D-printed denture base material. Additionally, to compare the mechanical properties of that 3D-printed material with those of conventional autopolymerizing and a heat-cured denture base material. A resin for 3D-printing denture base (Imprimo ®), a heat-polymerizing acrylic resin (Paladon ® 65), and an autopolymerizing acrylic resin (Palapress ®) were investigated. Flexural strength, elastic modulus, fracture toughness, work of fracture, water sorption, and water solubility were evaluated. The 3D-printed test specimens were post-cured using two different units (Imprimo Cure ® and Form Cure ®). The tests were carried out after both dry and 30 days water storage. Data were collected and statistically analyzed. Resin type had a significant effect on the flexural strength, elastic modulus, fracture toughness, and work of fracture (p < 0.001). The flexural strength and elastic modulus for the heat-cured polymer were significantly the highest among all investigated groups regardless of the storage condition (p < 0.001). The fracture toughness and work of fracture of the 3Dprinted material were significantly the lowest (p < 0.001). The heat-cured polymer had the lowest significant water solubility (p < 0.001). The post-curing method had an impact on the flexural strength of the investigated 3D-printed denture base material. The flexural strength, elastic modulus, fracture toughness, work of fracture of the 3D-printed material were inferior to those of the heat-cured one. Increased post-curing temperature may enhance the flexural properties of resin monomers used for 3D-printing dental appliances. Resumen: El objetivo de este trabajo fue investigar el efecto de dos métodos de poscurado en la Propiedades mecánicas de un material base para prótesis dental impreso en 3D. Además, para comparar la mecánica propiedades de ese material impreso en 3D con las de la autopolimerización convencional y un curado por calor material base de la dentadura postiza. Una resina para la impresión 3D de bases de prótesis dentales (Imprimo ®), un acrílico termopolimerizable Se investigaron una resina (Paladon ® 65) y una resina acrílica autopolimerizable (Palapress ®). Flexión Resistencia, módulo elástico, tenacidad a la fractura, trabajo de fractura, sorción de agua y solubilidad en agua. fueron evaluados. Las muestras de prueba impresas en 3D se curaron posteriormente utilizando dos unidades diferentes (Imprimo Cure® y Form Cure®). Las pruebas se llevaron a cabo después de un almacenamiento en seco y durante 30 días en agua. Datos fueron recolectados y analizados estadísticamente. El tipo de resina tuvo un efecto significativo sobre la resistencia a la flexión, módulo elástico, tenacidad a la fractura y trabajo de fractura (p < 0,001). La resistencia a la flexión y El módulo elástico para el polímero curado con calor fue significativamente el más alto entre todos los investigados. grupos independientemente de la condición de almacenamiento (p < 0,001). La tenacidad a la fractura y el trabajo de fractura. del material impreso en 3D fueron significativamente los más bajos (p <0,001). El polímero curado por calor tenía la solubilidad en agua significativa más baja (p < 0,001). El método de poscurado tuvo un impacto en la Resistencia a la flexión del material de base de la dentadura postiza impreso en 3D investigado. La resistencia a la flexión, elástica. El módulo, la tenacidad a la fractura y el trabajo de fractura del material impreso en 3D fueron inferiores a los del curado con calor. El aumento de la temperatura de poscurado puede mejorar las propiedades de flexión de la resina monómeros utilizados para aparatos dentales de impresión 3D.

Abstract: The aim of this in vitro study was to assess the mechanical properties of five commercially available subtractive computer-aided design and computer-aided manufacturing (CAD-CAM) milled splint materials, as well as to compare them with conventional heat-polymerized and autopolymerizing resins used in the con struction of conventional splints. Material and methods: Five CAD-CAM milled (ProArt CAD Splint, Therapon Transpa, Temp Premium Flexible Transpa, Cast, and Aqua), one autopolymerizing (Palapress), and one heat-polymerized (Paladon 65) resin materials were evaluated. Flexural strength, E-modulus, Vickers hardness, fracture toughness, fracture work, water sorption, and water solubility were measured. Samples were evaluated after dry and water storage for 30 days at 37 ? C. Data were collected and statistically analyzed. Results: Under both storage circumstances, the flexural strength values of Paladon 65, Therapon Transpa, Temp Premium Flexible Transpa, and Aqua were statistically non-significant (P=0.055). The polycarbonate-based CAD-CAM material Temp Premium Flexible Transpa had the highest statistically significant values of the frac ture toughness and fracture work (P<0.001). Moreover, it exhibited the lowest percentages of water sorption and water solubility among the investigated materials (P<0.001). All of the CAD-CAM materials exhibited dry elastic moduli greater than Palapress and lower than Paladon 65. One of the CAD-CAM materials, Cast, had the highest dry Vickers hardness value, which was nonsignificant when compared to Therapon Transpa (P=0.762). Conclusion: CAD-CAM polycarbonate-based splint materials exhibit higher fracture toughness and fracture work as well as lower water sorption and solubility than polymethyl methacrylate-based ones. The mechanical characteristics of the assessed CAD-CAM milled splint materials were not typically superior to those of the conventional heat-polymerized resin. However, some of them outperformed the autopolymerizing acrylic resin in terms of flexural strength, surface microhardness, water sorption, and water solubility. Resumen: El objetivo de este estudio in vitro fue evaluar las propiedades mecánicas de cinco disponibles comercialmente materiales de férula fresados de diseño sustractivo asistido por computadora y fabricación asistida por computadora (CAD-CAM), como así como compararlos con resinas convencionales polimerizadas por calor y autopolimerizantes utilizadas en la industria. Construcción de férulas convencionales. Material y métodos: Cinco fresados CAD-CAM (ProArt CAD Splint, Therapon Transpa, Temp Premium Flexible Transpa, Cast y Aqua), una resina autopolimerizable (Palapress) y una resina termopolimerizada (Paladon 65). Se evaluaron los materiales. Resistencia a la flexión, módulo E, dureza Vickers, tenacidad a la fractura, trabajo de fractura, Se midieron la sorción de agua y la solubilidad en agua. Las muestras se evaluaron después del almacenamiento seco y en agua durante 30 días a 37 ? C. Los datos fueron recolectados y analizados estadísticamente. Resultados: En ambas circunstancias de almacenamiento, los valores de resistencia a la flexión de Paladon 65, Therapon Transpa, Temp Premium Flexible Transpa y Aqua no fueron estadísticamente significativos (P = 0,055). La base de policarbonato El material CAD-CAM Temp Premium Flexible Transpa tuvo los valores estadísticamente significativos más altos de fractura tenacidad de la estructura y trabajo de fractura (P <0,001). Además, exhibió los porcentajes más bajos de sorción de agua y solubilidad en agua entre los materiales investigados (P<0,001). Todos los materiales CAD-CAM mostraron elasticidad seca. módulos mayores que Palapress e inferiores que Paladon 65. Uno de los materiales CAD-CAM, Cast, tuvo el mayor valor de dureza Vickers seco, que no fue significativo en comparación con Therapon Transpa (P = 0,762).

Abstract: Statement of problem: The fracture incidence of implant-supported overdentures is more frequent in the area of attachment because of stress concentration and denture deformation in this area. How Eglass fiber reinforcement can address this problem is unclear. Purpose: The purpose of this in vitro study was to evaluate the influence of unidirectional E-glass fiber reinforcement on the mid-line denture base strains of single implant-supported overdentures. Material and methods. An experimental acrylic resin cast was constructed with a single implant placed in the mid-line area and a ball attachment screwed to the implant. Twenty-four experimental overdentures were constructed and divided into 4 groups: group AP fabricated from autopolymerizing acrylic resin without fiber reinforcement, group APF fabricated from autopolymerizing acrylic resin with unidirectional E-glass fiber reinforcement running over the residual ridge and the ball matrix, group HP fabricated from heatpolymerized acrylic resin without fiber reinforcement, and group HPF fabricated from heat-polymerized acrylic resin with unidirectional E-glass fiber reinforcement running over the residual ridge and the ball matrix. A biaxial rosette strain gauge was attached to the incisor areas of each overdenture above the attachment level (Ch1, Ch2) and to a multichannel digital strain meter. A static vertical load of 100 N was applied to the first molar area bilaterally by using a universal testing device during strain measurement procedures. The differences in the mean strain and deflection values among the investigated groups were evaluated for statistical significance using 1-way analysis of variance (ANOVA) with the Tukey post hoc multiple comparison (a =.05). Results. The type of acrylic resin did not have a statistically significant effect on the mean strain values among groups (P=.350), while the reinforcement did significantly affect them (P<.001). The interaction between reinforcement and acrylic resin was not statistically significant (P=.552). Both strain gauge channels in group APF and group HPF recorded significantly lower strain values by almost 50% than those of group AP and group HP (P<.05). Conclusions. Unidirectional E-glass fiber reinforcement placed over the residual ridge and implant attachment significantly reduced denture base strains and deformation of single implantsupported overdentures. Resumen: Declaración del problema. La incidencia de fracturas de las sobredentaduras implantosoportadas es más frecuente en el área de inserción debido a la concentración de tensiones y la deformación de la dentadura postiza en esta área. No está claro cómo el refuerzo de fibra de vidrio E puede abordar este problema. Objetivo. El propósito de este estudio in vitro fue evaluar la influencia de unidireccional Refuerzo de fibra de vidrio E en la línea media de la base de la dentadura postiza de un solo implante. Material y métodos. Se construyó un modelo experimental de resina acrílica con un solo implante. colocado en la zona de la línea media y un accesorio de bola atornillado al implante. Veinticuatro se construyeron sobredentaduras experimentales y se dividieron en 4 grupos: grupo AP fabricado de resina acrílica autopolimerizable sin refuerzo de fibra, grupo APF fabricado con resina acrílica autopolimerizable con refuerzo de fibra de vidrio E unidireccional que recorre el cresta residual y matriz de bolas, grupo HP fabricados con resina acrílica termopolimerizada sin refuerzo de fibra, y grupo HPF fabricado a partir de resina acrílica termopolimerizada con Refuerzo unidireccional de fibra de vidrio E que recorre la cresta residual y la matriz de bolas. Se adjuntó un medidor de tensión de roseta biaxial a las áreas de los incisivos de cada sobredentadura por encima del nivel de conexión (Ch1, Ch2) y a un medidor de tensión digital multicanal.

Abstract: The research aimed to determine the tensile bond strength (TBS) between polymerized intact and ground fiber-reinforced composite (FRC) surfaces. FRC prepregs (a reinforcing fiber pre-impregnated with a semi-interpenetrating polymer network (semi-IPN) resin system; everStick C&B) were divided into two groups: intact FRCs (with a highly PMMA-enriched surface) and ground FRCs (with a low PMMA gradient). Each FRC group was treated with: StickRESIN and G-Multi PRIMER. These groups were further divided into four subgroups based on the application time of the treatment agents: 0.5, 1, 2, and 5 min. Next, a resin luting cement was applied to the FRC substrates on the top of the photo polymerized treating agent. Thereafter, weight loss, surface microhardness, and TBS were evaluated. Three-factor analysis of variance (p ? 0.05) revealed significant differences in the TBS among the FRC groups. The highest TBS was recorded for the intact FRC surface treated with G-Multi PRIMER for 2 min (13.0 ± 1.2 MPa). The monomers and solvents of G-Multi PRIMER showed a time-dependent relationship between treatment time and TBS. They could diffuse into the FRC surface that has a higher PMMA gradient, further resulting in a high TBS between the FRC and resin luting cement. Resumen: La investigación tuvo como objetivo determinar la resistencia a la tracción (TBS) entre polimerizados Superficies compuestas reforzadas con fibra (FRC) intactas y rectificadas. Prepregs de FRC (una fibra de refuerzo preimpregnado con un sistema de resina de red polimérica semiinterpenetrante (semi-IPN); siempreStick C&B) se dividieron en dos grupos: FRC intactos (con una superficie altamente enriquecida en PMMA) y molidos. FRC (con un gradiente bajo de PMMA). Cada grupo de FRC fue tratado con: StickRESIN y G-Multi CEBADOR. Estos grupos se dividieron en cuatro subgrupos según el tiempo de aplicación del agentes de tratamiento: 0,5, 1, 2 y 5 min. A continuación, se aplicó un cemento de resina a los sustratos de FRC. en la parte superior del agente de tratamiento fotopolimerizado. Posteriormente, pérdida de peso, microdureza superficial, y TBS fueron evaluados. El análisis de varianza de tres factores (p ? 0,05) reveló diferencias significativas en el TBS entre los grupos del FRC. El TBS más alto se registró para la superficie intacta de FRC tratada con G-Multi PRIMER durante 2 min (13,0 ± 1,2 MPa). Los monómeros y disolventes de G-Multi PRIMER mostró una relación dependiente del tiempo entre el tiempo de tratamiento y TBS. Podrían difundirse hacia el Superficie de FRC que tiene un gradiente de PMMA más alto, lo que resulta además en un TBS alto entre el FRC y Cemento de fijación de resina.