Tesis de Aristides Lores para obtener el título de doctor en Medicina y Cirugía de la Facultad de Medicina en la Universidad Nacional de Colombia en 1892. A lo largo del documento Lores estudia la peritonitis tuberculosa, complicación producida por inflamación del intestino. El autor define la enfermedad, su historia, etiología, causas predisponentes, causas determinantes, sintomatología, y otras particularidades como la enquistada o ulcerosa de la misma, anatomía patológica, marcha de las formas crónicas, diagnóstico, tratamiento y tratamiento quirúrgico. Finalmente, Lores presenta observaciones sobre la autopsia realizada a tres personas que murieron de esa enfermedad.

Los medios de comunicación, y en el caso específico de la prensa mexicana generalista, se han sumado a la creciente tendencia mundial de generar contenidos para los diferentes dispositivos móviles (teléfonos inteligentes, tabletas, e-readers, etc.) de acuerdo a las diversas plataformas o sistemas operativos móviles que corren en ellos (iOS, Android, BlackBerry, etc.), ya sea, entre otros, como forma de explorar nuevos canales de distribución de información noticiosa y nuevos modelos de pago. La investigación presenta un breve recorrido sobre bibliografía previa en el ámbito del periodismo móvil, enfatizando en la perspectiva que atañe, los móviles como un nuevo soporte para la adaptación, distribución y venta de contenido noticioso generado por las industrias periodísticas, en este caso la prensa. A partir de esto la construcción de un marco teórico que abarca la explicación sobre qué es lo móvil (redes móviles, dispositivos móviles, plataformas móviles e internet móvil); para luego aterrizar en el periodismo móvil (su definición, contenidos periodísticos en móviles, la prensa en los móviles, qué deben tener en cuenta los periódicos a la hora de incursionar en móviles, y modelo de negocio).  La investigación de carácter exploratorio y descriptivo, implementó el método de observación directa no participante estructurada y dividió el estudio en dos etapas. Una primera donde se realizó una observación general a la prensa mexicana generalista en plataformas móviles, y una segunda que consistió en la observación específica, como casos de estudio, a El Universal (diario generalista nacional) y El Norte (diario generalista regional) en las plataformas móviles que registraron mayor adopción, iOS (iPhone, iPod Touch y iPad) y el e-reader Kindle. Más adelante se presentan los hallazgos “en duro”, tanto la observación general como la observación específica, desglosándose los mismos por cada una de las categorías que se establecieron para la investigación. En la interpretación de los hallazgos se destacan aspectos como la preferencia de la prensa mexicana generalista por el desarrollo de aplicaciones para iOS de Apple (tableta iPad, teléfono inteligente iPhone, reproductor multimedia portátil iPod Touch) por encima de cualquier otra plataforma, el desarrollo de otras aplicaciones de productos informativos y noticiosos propios de la casa editorial, la escasa presencia en e-readers (sólo en el Kindle de Amazon), el cambio de roles (el propietario de la plataforma / dispositivo móvil es el nuevo intermediario, y los medios de comunicación, entre ellos la prensa, pasan a ser uno más de los proveedores de contenido, en este caso noticioso), los medios de comunicación, entre ellos la prensa, deben adaptarse a las políticas y reglamentaciones que exigan los propietarios de las plataformas / dispostivos si quieren hacer presencia en ellos, así entre otros aspectos. Por otro lado, se encontró que la aplicación de El Norte para iOS (iPhone / iPod Touch) era rica en contenido y estable, la de El Universal para iOS (iPhone / iPod Touch) rica en contenido pero con prolemas de estabilidad y de arquitectura informativa; la de El Norte para iOS (iPad) rica en contenido pero con problemas de estabilidad y limitada en funciones; la de El Universal para iOS (iPad) limitada en contenido, escasas funciones, lenta y extremadamente inestable; y El Universal en Kindle que respondía a lo solicitado por Amazon para este tipo de publicaciones. Vale mencionar que la investigación es pionera en su temática, ya que hasta donde la bibliografía consultada lo permitió determinar, no se encontraron otros estudios de similarescaracterísticas desarrollados en algún país latinoamericano de habla hispana.

The excavation for the 53-story reinforced concrete One Museum Park West building (OMPW) in Chicago was constructed using combined support systems. The building was supported by caissons and a perimeter wall formed by secant piles which transitioned to tangent piles below the bottom of the cut. After installing the perimeter wall and deep foundations for the building, the excavation for the reinforced concrete central core was supported by a circular cofferdam made of sheet piles and steel ring beams. This excavation was made using conventional bottom-up excavation techniques. The excavation for the rest of the building was made using a top-down method and was laterally braced with reinforced concrete floor slabs structurally connected to the secant pile walls and the reinforced concrete core. Field performance data during construction of the OMPW basements were collected with settlement points, inclinometers and strain gages installed in the concrete basement slabs. Significant settlements were observed adjacent to the excavation during wall and deep foundation installation, central core construction and top-down excavation. The influence of concrete material time-dependence of the floor slabs on the performance during top-down excavation is evaluated and a method for the separation of temperature-related strains from the excavation-induced strains in the concrete is described. The construction of the basements is simulated with a 3D numerical structural model to study the influence of the concrete material time-dependence of the floor slabs in the excavation-induced movements resulting from top-down construction. Computed strains in the floor slabs are compared with the observed performance data collected from the strain gages. For use in numerical simulation of the entire excavation process, hypoplasticity constitutive parameters for clays (HC model) at the element test level were calibrated with tests conducted on high quality block samples obtained from the excavation of Block 37 project in Chicago. They included oedometer tests, bender element measurements, and triaxial tests following different stress probes, and were further refined with seismic cone penetration results.  The entire OMPW excavation is simulated with the calibrated parameters with a fully coupled-flow deformation, three-dimensional finite element model. Influence of the construction of secant pile walls, concrete material time-dependence, and nonlinear concrete behavior of the perimeter pile walls on the performance of the OMPW excavation is determined. Conclusions about top-down construction are drawn in light of the measured and simulated performance of the OMPW excavation.

Sustainability-oriented innovation (SOI), which is innovation directed at improving social, environmental, and economic conditions, is being studied and used as a way to address the risks and opportunities organisations have in these three areas. This research explores the use of Performance Management (PM), meaning the strategy and processes used in organisations to define and improve performance, as a way to develop SOI capabilities in companies. The conceptual model used is based around four concepts: SOI, which describes what is to be achieved, organisations, or learning organisations, as the place where this can happen, PM, which explains how this can be accomplished, and individuals and teams as the central subject that describe who is this targeted for. The research was based on a literature review around these areas and a set of semi-structured interviews to managers and senior directors of large multinational organisations with innovation or sustainability related roles. Through the analysis and interpretation of this data, the results validated the effectiveness of PM to improve SOI in organisations, as well as uncovering six specific opportunity areas to leverage it more effectively. The latter are summarised as: purpose or vision offering direction, values that enable autonomy and celebrate trying, daring and shared goals, resources committed for the long run, sustainability literacy, and enabling business processes. The research contributes to the literature by outlining pathways to connect sustainability practices with other business practices, especially Human Resources, the area of study of PM. Additionally, it contributes to the practice of SOI by providing guidelines to identify and act on potential areas of opportunities to leverage on PM to develop SOI capabilities.

Abstract: Floods are disastrous natural severe weather events that cause large damage worldwide each year, inducing loss of human lives, destruction of infrastructure and economical losses. Consequently, forecasting this type of events through hydrological modelling is of great importance from a civil protection point of view since it allows institutions to reduce the generated hydrological risk by means of early warning systems. Nevertheless, ungauged basins where there is lack of direct measurements of meteorological information to force the models is one encountered problematic affecting the forecasts. In the present study is evaluated the possibility of using meteorological predictions coming from MOLOCH model to force the FEST-WB hydrological model to perform discharge forecasting. This, under the hypothesis that the committed error of the prediction is negligible when using forecasts up to 24 h. The study is done in a well-known area such as the Seveso-Olona-Lambro river basins located in northern Italy. Thus, the main hydro-meteorological variables are analysed by carrying out a comparison between spatialized observed meteorological data coming from ARPA and meteonetwork weather stations and meteorological predictions. Moreover, a sensitivity analysis following the one-factor-at-time methodology is accomplished with the aim of defining which forcing mostly affects flowrate forecasts. It is shown that discreet correspondence of information with an underestimation trend – particularly for large values - is verified for discharge at hourly and daily scale, and that underestimation of precipitation - especially in summer - and overestimation of solar radiation are the main reasons of this. Hence, to improve the predictability when coupling the two models, some actions should be evaluated to enhance the correspondence of the meteorological forcings. Resumen: Las inundaciones son desastres naturales que causan una gran cantidad de daño alrededor del mundo cada año, induciendo pérdidas de vidas humanas, destrucción de infraestructura y pérdidas económicas. En consecuencia, la predicción de este tipo de eventos a través de modelos hidrológicos es de suma importancia desde el punto de vista de la protección civil ya que permite a las instituciones reducir el riesgo hidrológico creado, por medio de sistemas de alerta temprana. Sin embargo, cuencas hidrográficas sin instrumentación en las que existe una falta de mediciones directas de información meteorológica para inicializar los modelos, es una problemática encontrada que afecta a las predicciones. En el presente estudio se evalúa la posibilidad de usar predicciones meteorológicas obtenidas con el modelo MOLOCH para inicializar el modelo hidrológico FEST-WB y así realizar predicciones de caudal. Lo anterior se realiza hipotetizando que el error cometido en la predicción de caudal resulta ser insignificante cuando se utilizan predicciones meteorológicas hasta las primeras 24 h. El estudio se realiza en un área ampliamente estudiada como la cuenca de los ríos Seveso-Olona-Lambro localizados en el norte de Italia. De este modo, las principales variables hidro-meteorológicas son analizadas llevando a cabo una comparación entre información meteorológica observada y espacializada, obtenida a partir de las estaciones climáticas de ARPA y meteonetwork, y las predicciones meteorológicas. Adicionalmente, se efectúa un análisis de sensibilidad con la metodología “un factor a la vez” (one-factor-at-time) con el objetivo de definir cuál de las forzantes afecta mayoritariamente las predicciones de caudal. Se evidencia que para los caudales a escalas horaria y diaria existe una correspondencia de información discreta con una tendencia a la subestimación, particularmente para valores elevados, y que, la subestimación de la precipitación (especialmente en verano) y la sobreestimación de la radiación solar son las razones principales de este comportamiento. Por consiguiente, para mejorar la predictibilidad cuando se acoplan los dos modelos mencionados, acciones adicionales deben ser evaluadas para realzar la correspondencia de las forzantes meteorológicas.

Abstract: Floods are disastrous natural severe weather events that cause large damage worldwide each year, inducing loss of human lives, destruction of infrastructure and economical losses. Consequently, forecasting this type of events through hydrological modelling is of great importance from a civil protection point of view since it allows institutions to reduce the generated hydrological risk by means of early warning systems. Nevertheless, ungauged basins where there is lack of direct measurements of meteorological information to force the models is one encountered problematic affecting the forecasts. In the present study is evaluated the possibility of using meteorological predictions coming from MOLOCH model to force the FEST-WB hydrological model to perform discharge forecasting. This, under the hypothesis that the committed error of the prediction is negligible when using forecasts up to 24 h. The study is done in a well-known area such as the Seveso-Olona-Lambro river basins located in northern Italy. Thus, the main hydro-meteorological variables are analysed by carrying out a comparison between spatialized observed meteorological data coming from ARPA and meteonetwork weather stations and meteorological predictions. Moreover, a sensitivity analysis following the one-factor-at-time methodology is accomplished with the aim of defining which forcing mostly affects flowrate forecasts. It is shown that discreet correspondence of information with an underestimation trend – particularly for large values - is verified for discharge at hourly and daily scale, and that underestimation of precipitation - especially in summer - and overestimation of solar radiation are the main reasons of this. Hence, to improve the predictability when coupling the two models, some actions should be evaluated to enhance the correspondence of the meteorological forcings. Resumen: Las inundaciones son desastres naturales que causan una gran cantidad de daño alrededor del mundo cada año, induciendo pérdidas de vidas humanas, destrucción de infraestructura y pérdidas económicas. En consecuencia, la predicción de este tipo de eventos a través de modelos hidrológicos es de suma importancia desde el punto de vista de la protección civil ya que permite a las instituciones reducir el riesgo hidrológico creado, por medio de sistemas de alerta temprana. Sin embargo, cuencas hidrográficas sin instrumentación en las que existe una falta de mediciones directas de información meteorológica para inicializar los modelos, es una problemática encontrada que afecta a las predicciones. En el presente estudio se evalúa la posibilidad de usar predicciones meteorológicas obtenidas con el modelo MOLOCH para inicializar el modelo hidrológico FEST-WB y así realizar predicciones de caudal. Lo anterior se realiza hipotetizando que el error cometido en la predicción de caudal resulta ser insignificante cuando se utilizan predicciones meteorológicas hasta las primeras 24 h. El estudio se realiza en un área ampliamente estudiada como la cuenca de los ríos Seveso-Olona-Lambro localizados en el norte de Italia. De este modo, las principales variables hidro-meteorológicas son analizadas llevando a cabo una comparación entre información meteorológica observada y espacializada, obtenida a partir de las estaciones climáticas de ARPA y meteonetwork, y las predicciones meteorológicas. Adicionalmente, se efectúa un análisis de sensibilidad con la metodología “un factor a la vez” (one-factor-at-time) con el objetivo de definir cuál de las forzantes afecta mayoritariamente las predicciones de caudal. Se evidencia que para los caudales a escalas horaria y diaria existe una correspondencia de información discreta con una tendencia a la subestimación, particularmente para valores elevados, y que, la subestimación de la precipitación (especialmente en verano) y la sobreestimación de la radiación solar son las razones principales de este comportamiento. Por consiguiente, para mejorar la predictibilidad cuando se acoplan los dos modelos mencionados, acciones adicionales deben ser evaluadas para realzar la correspondencia de las forzantes meteorológicas.

CD34+ cell dose in the transplanted product is still considered a measure of the engraftment potential in haemopoietic stem cell transplantation (HSCT). CD34+ selected products are characterised by their high purity and depleted T-cells. These characteristics have made them traditionally suitable to decrease the incidence of graft versus host disease, particularly in haploidentical HSCT. The CliniMACS is a state of the art cell sorting system based on magnetic particles conjugated to CD34 antibodies. This study retrospectively evaluated the CliniMACS system performance in terms of CD34+ purity and cell recovery, and T-cell depletion in the selected product. The results were compared against target values fixed by the processing centre, as well as against published data. Factors affecting the CD34+ cell recovery were also investigated and a pilot study was carried out to assess the effect of cryopreservation on the viability of the selected products. In total, 151 procedures were analysed. The mean recovery and purity were 64.82 + 16.19 and 88.0 + 11.0% respectively. The mean T-cell depletion was 4.7021 + 0.5129 logs. Only purity was slightly below the specification (90%), with the lowest values obtained from peripheral blood (PB) collections. Factors affecting the recoveries were the overall age of the product (p=0.001), overnight storage (p=0.002), and the use of a particular tubing set with the instrument (p=0.002). The mean CD34+ viability was not significantly different to the value before cryopreservation (p=0.068). Results from this study were comparable with published data of the CliniMACS system performance. Local investigations regarding the purity of PB products should be performed. For the first time, using a magnetic separation method, factors affecting CD34+ recovery were identified. The significance of the effect of product age and overnight storage on cell recovery, provide a rationale for further prospective studies

Jake Thorson, the Vikings team captain, gets all the credit. He leads the team in home runs, and everybody loves him for it -- that is, everyone but his brother, Luke. Luke isn't popular, and he hasn't hit a single home run -- but he does have the team's best batting average as well as the most stolen bases. However, those types of things don't really get you the attention that a homer does, and Luke's tired of standing in the Jake's shadow.

In this volume of Air Gear, the unthinkable has occurred: the minds of Emily Adachi and United States President Omaha have switched bodies! Omaha speaks about his desire for Air Treck technology to be used for the good of all humanity. Meanwhile, Team Trident is plunged into a bloody battle as mysterious invaders descend upon Osaka!

The true motives of the original Sleeping Forest are revealed as Spitfire makes his move in a confrontation with a surprise enemy. Kazu is chosen to be the successor to the Flame Road, but does that mean that it's the end of the road for Spitfire?