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Imagen de apoyo de  Otras miradas : arte y ciegos: tan lejos, tan cerca

Otras miradas : arte y ciegos: tan lejos, tan cerca

Por: Rosa Gratacós | Fecha: 2009

Diferentes miradas se esbozan y se reflejan, se cruzan y se interrogan a partir de las experiencias y reflexiones que se presentan en esta obra. En ella se reflexiona sobre el significado del arte para los ciegos a través del relato de diferentes propuestas realizadas con personas invidentes. Otras miradas. Las miradas que se logran al utilizar integralmente los sentidos. Las miradas que trascienden lo visual para convertirse en imágenes interiores. Las miradas sobre la educación artística. Una educación que entendemos como pluralista. Que debería potenciar el aprendizaje y la construcción de...
Fuente: Digitalia Formatos de contenido: Libros
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Otras miradas : arte y ciegos: tan lejos, tan cerca

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Imagen de apoyo de  El lazareto

El lazareto

Por: Francisco Bayón | Fecha: 1880

Impreso redactado por el presidente de la Junta de beneficencia de Agua de Dios, en el que expone a los miembros de la Cámara de representantes el panorama, a su juicio deplorable, en el que se encuentra el lazareto de esta población y las dificultades de vida de los enferemos al interior de él. El documento conserva la ortografía de la época.
Fuente: Biblioteca Virtual Banco de la República Formatos de contenido: Prensa
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El lazareto

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Imagen de apoyo de  Plan profilactico i curativo de la viruela: 28 de Julio de 1840

Plan profilactico i curativo de la viruela: 28 de Julio de 1840

Por: Joaquín Sarmiento | Fecha: 1881

Plan de curación y prevención contra la viruela, presentado a la Facultad de Medicina de Bogotá en 1840, por orden del Gobierno nacional. En el documento, además de mostrar cómo se ha combatido la enfermedad en otros lugares, se mencionan las cuatro etapas que comprende el desarrollo de la epidemia y los cuidados que se deben tener para no contagiarse.
Fuente: Biblioteca Virtual Banco de la República Formatos de contenido: Prensa
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Plan profilactico i curativo de la viruela: 28 de Julio de 1840

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Imagen de apoyo de  Performance Evaluation Of The Clinimacs System For The Positive Selection Of CD34+ Cells From Stem Cell Products Factors Affecting CD34+ Cell Recovery

Performance Evaluation Of The Clinimacs System For The Positive Selection Of CD34+ Cells From Stem Cell Products Factors Affecting CD34+ Cell Recovery

Por: Guillermo Andrés Orjuela Falla | Fecha: 2009

CD34+ cell dose in the transplanted product is still considered a measure of the engraftment potential in haemopoietic stem cell transplantation (HSCT). CD34+ selected products are characterised by their high purity and depleted T-cells. These characteristics have made them traditionally suitable to decrease the incidence of graft versus host disease, particularly in haploidentical HSCT. The CliniMACS is a state of the art cell sorting system based on magnetic particles conjugated to CD34 antibodies. This study retrospectively evaluated the CliniMACS system performance in terms of CD34+ purity and cell recovery, and T-cell depletion in the selected product. The results were compared against target values fixed by the processing centre, as well as against published data. Factors affecting the CD34+ cell recovery were also investigated and a pilot study was carried out to assess the effect of cryopreservation on the viability of the selected products. In total, 151 procedures were analysed. The mean recovery and purity were 64.82 + 16.19 and 88.0 + 11.0% respectively. The mean T-cell depletion was 4.7021 + 0.5129 logs. Only purity was slightly below the specification (90%), with the lowest values obtained from peripheral blood (PB) collections. Factors affecting the recoveries were the overall age of the product (p=0.001), overnight storage (p=0.002), and the use of a particular tubing set with the instrument (p=0.002). The mean CD34+ viability was not significantly different to the value before cryopreservation (p=0.068). Results from this study were comparable with published data of the CliniMACS system performance. Local investigations regarding the purity of PB products should be performed. For the first time, using a magnetic separation method, factors affecting CD34+ recovery were identified. The significance of the effect of product age and overnight storage on cell recovery, provide a rationale for further prospective studies
Fuente: Biblioteca Virtual Banco de la República Formatos de contenido: Tesis
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Performance Evaluation Of The Clinimacs System For The Positive Selection Of CD34+ Cells From Stem Cell Products Factors Affecting CD34+ Cell Recovery

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Imagen de apoyo de  Payment method as a predictor of daily distress experienced by physicians

Payment method as a predictor of daily distress experienced by physicians

Por: Juan Nicolás; Bermedo Carrasco Peña Sánchez | Fecha: 2014

Background: Physicians face intrinsic tensions when practicing medicine; therefore, extrinsic factors that could affect distress, such as payment methods, need to be assessed. The study objectives were to: compare levels of distress by payment method, identify factors predicting distress in a two-level regression model, and explore interactions between predictors of distress and payment method. Methods: A cross-sectional study was conducted among physicians in the Saskatoon Health Region, Saskatchewan. Physicians completed a pre-tested questionnaire about their distress. Analysis of variance was used to compare distress levels of physicians paid by fee-for-service (FFS), alternative payment plans (APPs), and blended methods. A mixed linear regression model was built to predict distress with geographical area of practice as the random component. Demographics, workload, complexity of patients, payment method, career satisfaction, and practice profile were the independent variables. The interactions between payment method and predictors of daily distress were evaluated. Results: A total of 382 physicians participated. Response bias was tested and found to be negligible. In the multivariable analysis, payment method was a predictor of distress which interacted with the proportion of complex cases. Lower levels of distress were found among physicians who had more than 75% of patients with complex conditions and were paid by APPs, compared to those paid by FFS and blended methods. Career satisfaction was found to be an important predictor. Nine percent of the outcome variation was explained by geographic area of practice. Conclusions: Payment method is a predictor of distress when adjusting by confounders, interacting with proportion of complex cases. APPs may promote provision of care for patients with complex conditions. Career satisfaction can be considered a protective indicator of distress. Practice environment influences distress experienced by physicians.
Fuente: Biblioteca Virtual Banco de la República Formatos de contenido: Artículos
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Payment method as a predictor of daily distress experienced by physicians

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Imagen de apoyo de  Live imaging of mitosomes and hydrogenosomes by halotag technology

Live imaging of mitosomes and hydrogenosomes by halotag technology

Por: David Esteban; De Napoli Sanín Peña | Fecha: 2012

Hydrogenosomes and mitosomes represent remarkable mitochondrial adaptations in the anaerobic parasitic protists such as Trichomonas vaginalis and Giardia intestinalis, respectively. In order to provide a tool to study these organelles in the live cells, the HaloTag was fused to G. intestinalis IscU and T. vaginalis frataxin and expressed in the mitosomes and hydrogenosomes, respectively. The incubation of the parasites with the fluorescent Halo-ligand resulted in highly specific organellar labeling, allowing live imaging of the organelles. With the array of available ligands the HaloTag technology offers a new tool to study the dynamics of mitochondria-related compartments as well as other cellular components in these intriguing unicellular eukaryotes.
Fuente: Biblioteca Virtual Banco de la República Formatos de contenido: Artículos
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Live imaging of mitosomes and hydrogenosomes by halotag technology

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Imagen de apoyo de  Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applications

Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applications

Por: María Isabel; Gil Castellanos Arboleda | Fecha: 2015

To improve cardiovascular implant success, metal-based stents are designated to modulate endothelial cells adhesion and migration in order to prevent restenosis and late thrombosis diseases. Biomimetic coatings with extra-cellular matrix adhesive biomolecules onto stents surfaces are a strategy to recover a healthy endothelium. However, the appropriate bioactive sequences to selective promote growth of endothelium and the biomolecules surface immobilization strategy remains to be elucidated. In this study, biofunctionalization of cobalt chromium, CoCr, alloy surfaces with elastin-like recombinamers, ELR, genetically modified with an REDV sequence, was performed to enhance metal surfaces endothelialization. Moreover, physical adsorption and covalent bonding were used as biomolecules binding strategies onto CoCr alloy. Surfaces were activated with plasma and etched with sodium hydroxide previous to silanization with 3-chloropropyltriethoxysilane and functionalized with the ELR. CoCr alloy surfaces were successfully biofunctionalized and the use of an ELR with an REDV sequence, allows conferring bioactivity to the biomaterials surface, demonstrating a higher cell adhesion and spreading of HUVEC cells on the different CoCr surfaces. This effect is emphasized as increases the amount of immobilized biomolecules and directly related to the immobilization technique, covalent bonding, and the increase of surface charge electronegativity. Our strategy of REDV elastin-like recombinamers immobilization onto CoCr alloy surfaces via covalent bonding through organosilanes provides a bioactive surface that promotes endothelial cell adhesion and spreading.
Fuente: Biblioteca Virtual Banco de la República Formatos de contenido: Artículos
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Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applications

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Imagen de apoyo de  ¿Existe una degeneración colectiva en Colombia?

¿Existe una degeneración colectiva en Colombia?

Por: Emilio Robledo Correa | Fecha: 1920

Artículo en el que Emilio Robledo refuta los argumentos de la ponencia que el doctor Miguel Jiménez presentó durante el Tercer Congreso Médico de Colombia (1918), en la que se explican las condiciones climáticas, geográficas y físicas que hacen que en Colombia haya una degeneración colectiva. A lo largo del documento Robledo ofrece varios argumentos por los que, a su juicio, Jiménez está equivocado y debe replantear sus hipótesis sobre determinismo geográfico aplicado a la medicina.
Fuente: Biblioteca Virtual Banco de la República Formatos de contenido: Tesis
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¿Existe una degeneración colectiva en Colombia?

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Identidades perdidas

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Aquí estamos... mutando

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