Abstract: Introduction: The occlusion of coronary grafts used during myocardial revascularization surgery is a relatively frequent event. It has been described that between 7–15% are affected before 24 hours, and up to 30% per year being mainly related to technical errors. Pulsed Doppler offers the necessary requirements for an adequate intraoperative evaluation of grafts. The main objective of this study is to demonstrate it using the Fluxvisum prototype. Material and method: Longitudinal study carried out between March 2012 and June 2016 in surgically revascularized patients in which the elaborated coronary grafts were evaluated intraoperatively using pulsed Doppler. Results: 110 patients were studied, predominantly men older than 60 years, with a high prevalence of HT, DM and previous AMI, and diagnosis on admission to NSTEMI. The average measurements were: Qmed:31.7ml/min, PI:3.2, DFI:70.2. The Qmed was the flowmeter variable that was most statistically associated with the appearance of major cardiac events. In the logistic regression, the quality of LAD revascularization stood out as the main predictor of MACE (p=0.050, OR:2.599, 95%CI:0.972-6.947), death (p=0.004, OR:13.947, 95%CI:2,311-84,163), AMI (p=0.000, OR:11.331, 95%CI:2.995-42.867) and perioperative acute ischemia (p=0.049, OR:2.864, 95%CI:0.997-8.222). Conclusions: Pulsed Doppler flowmetry proved to be a tool with high prognostic power as a predictor of postoperative comorbidity and major cardiac events in surgically revascularized patients. Resumen: Introducción: La oclusión de los injertos coronarios utilizados durante la cirugía de revascularización miocárdica es un hecho relativamente frecuente. Se ha descrito que entre el 7–15% se afectan antes de las 24 horas, y hasta un 30% al año relacionándose principalmente con errores técnicos. El Doppler pulsado ofrece los requerimientos necesarios para una adecuada evaluación intraoperatoria de los injertos. El objetivo principal de este estudio es demostrarlo utilizando el prototipo Fluxvisum. Material y método: Estudio longitudinal realizado entre marzo de 2012 y junio del 2016 en pacientes revascularizados quirúrgicamente en los que los injertos coronarios elaborados fueron evaluados intraoperatoriamente utilizando Doppler pulsado. Resultados: Se estudiaron 110 enfermos predominantemente hombres mayores de 60 años, con una alta prevalencia de hipertensión arterial (HTA), diabetes mellitus (DM) e infarto agudo de miocardio (IMA) previo, y diagnostico al ingreso de SCASEST. Las mediciones promedio fueron: Qmed:31,7ml/min, IP:3,2, DFI:70,2. El Qmed fue la variable flujométrica que más se asoció estadísticamente con la aparición de eventos cardiacos mayores. En la regresión logística, la calidad de la revascularización de la DA destacó como el principal factor predictor de MACE (p=0,050, OR:2,599, CI95%:0,972–6,947), muerte (p=0,004, OR:13,947, CI95%:2,311–84,163), IMA (p=0,000, OR:11,331, CI95%:2,995–42,867) e isquemia aguda perioperatoria (p=0,049, OR:2,864, CI95%:0,997–8,222). Conclusiones: La flujometría con Doppler pulsado demostró ser una herramienta que tiene un alto poder pronóstico como predictor de comorbilidad posoperatoria y eventos cardiacos mayores en pacientes revascularizados quirúrgicamente.

Abstract: Visionary Brazilian families have been instrumental in establishing the impact investing ecosystem in Brazil. Today Brazilian families are accelerating the impact investing sector by establishing new impact funds, testing new interventions and business models, engaging in field building, and transforming the impact of their operating businesses. There are a growing number of ways for families to create shared, sustainable prosperity in Brazil through business and investments. This report analyzes the history and current trends of how families are pursuing positive impact by aligning their investments and business activities with their values and legacy. The insights in this paper gathered from twenty-five leading families and ecosystem players provide inspiration and a path to action for families planning the next steps in their impact investing journey. This report outlines how the education, healthcare, and environmental preservation sectors are particularly well suited to attract impact investments in Brazil in the future. The challenges Brazil faces provide a diverse set of opportunities for families to deploy impact capital across asset classes, sectors, geographies, impact strategies, and return profiles. Resumen: Visionaras familias brasileñas han sido fundamentales en el establecimiento del ecosistema de inversión de impacto en Brasil. Hoy en día, las familias brasileñas están acelerando el sector de la inversión de impacto estableciendo nuevos fondos de impacto, probando nuevas intervenciones y modelos de negocio, participando en la construcción del ecosistema y transformando el impacto de sus negocios operativos. Hay un número creciente de formas en las que las familias pueden crear prosperidad compartida y sostenible en Brasil a través de negocios e inversiones. Este informe analiza la historia y las tendencias actuales de cómo las familias buscan un impacto positivo alineando sus inversiones y actividades comerciales con sus valores y legado. Los conocimientos en este documento recopilados de veinticinco familias líderes y actores del ecosistema brindan inspiración y un camino hacia la acción para las familias que planean los próximos pasos en su viaje de inversión de impacto. Este informe describe cómo los sectores de educación, salud y preservación del medio ambiente son particularmente adecuados para atraer inversiones de impacto en Brasil en el futuro. Los desafíos que enfrenta Brasil brindan un conjunto diverso de oportunidades para que las familias desplieguen capital de impacto en clases de activos, sectores, geografías, estrategias de impacto y perfiles de retorno.

Resumen: Este artículo busca señalar el vínculo entre la filosofía de Emmanuel Lévinas y la educación —παιδεία—. Al tomar distancia de intentos de aplicación axiológica y deontológica de la ética levinasiana en la educación, se sostiene que más allá de instrumentalizar las categorías fundamentales del pensador lituano, se trata de comprender el sentido de su filosofía y la forma como este puede enriquecer la praxis pedagógica. El trabajo se desarrolla en seis pasos: (1) caracterización de la filosofía levinasiana como descentramiento de la subjetividad y de su preeminencia ética; (2) descripción de dos ámbitos de la experiencia humana —gozo y Deseo—, que marcan (3) dos tipos diversos de educación: para la alimentación y para la responsabilidad hacia el Otro; (4) caracterización del mundo actual como mundo del trabajo, del cálculo, de la habilidad y de la relación de medios y fines, en el que (5) los ámbitos de aparición de un tercero —política, economía, justicia, educación— pretenden degradar la ética a un segundo plano; y (6) la necesidad de poner el rostro del Otro como centro del acto educativo.

Abstract: The metropolises of the global south are often considered out of rules as a distinct urban “species” while cities of the global north are commonly recognized for their development, organization, and operation. The duality that arises in Latin American cities is between the advancement of its infrastructure and the provision of goods and services. This duality is physically manifested in urban space, as well as the increase of spatial segregation and social inequality. Fragments, patches, archipelagos, and countless denominations that narrow the “disorder” of these cities contrast with the good practices they develop to increase the quality of life of their inhabitants. Life in public space is one of the interrelationships that occur in cities, but in some spaces in Latin American cities are considered fragments and uncertain spaces of the city without defined uses due to the characteristics of some of these spaces. These spaces, specifically in Colombian cities, commonly divide the large areas of poverty with the few areas of wealth, providing greater inequality and socio-spatial segregation. Considering Latin America as the most violent and inequitable region in the world explains why the research of recent decades in these cities has focused on understanding the causes and finding answers to minimize poverty, and inequality. These phenomena will not find the full answers in architecture nor urbanism; however, actions from these two disciplines are required to materialize opportunities for all the cities. Thus, the purpose of the research, based on literature review, methodological terms, and collection of information is reframing the role of public space as a potential for articulation with the deficit of public space and as a tool of urban development.

Abstract: Physicians are no strangers to situations where they have to decide with resource restrictions and uncertainty on the relative needs of future beneficiaries of the scarce resources. We propose a lab experiment to understand if such an environment affects physicians' resource allocation decisions and how. When there are incentives to overtreat, we find that a patient tended by a constrained physician under uncertainty obtains higher benefits and receives allocations closer to her optimum than patients from physicians with no constraints or deciding under uncertainty alone. In addition, we observe a redistribution of resources when physicians decide with resource restrictions and uncertainty. In particular, when resources are scarce, physicians tend to allocate the limited services to patients with higher benefits in the absence of medical services, a higher capacity to benefit from the resources, the scantiest need for service units, and the lowest benefits at the optimum. Finally, we find that constraints, with or without complete information on patient characteristics, lead selfish physicians to approximate what is best for the patient. Resumen: Los médicos no son ajenos a situaciones en las que tienen que decidir bajo escasez de recursos e incertidumbre sobre las necesidades relativas de los futuros beneficiarios de servicios de salud. Proponemos un experimento de laboratorio para entender sí, y cómo, este entorno afecta a las decisiones de asignación de recursos de los médicos. Cuando hay incentivos para la sobre provisión de servicios médicos, encontramos que los pacientes atendidos por médicos que enfrenta restricciones e incertidumbre obtienen mayores beneficios en salud y reciben servicios de salud más cercanos a su óptimo, en comparación con los pacientes vistos por médicos sin restricciones o que deciden sólo bajo incertidumbre. Además, observamos una redistribución de recursos cuando los médicos deciden bajo restricciones e incertidumbre. En particular, cuando los recursos son escasos, los médicos tienden a asignar servicios de salud a los pacientes con mayores beneficios en ausencia de servicios médicos, con mayor capacidad para beneficiarse de servicios adicionales, con menores necesidades de tratamiento médico y con menores beneficios en el óptimo. Por último, encontramos que las restricciones, con o sin información completa sobre las características del paciente, llevan a los médicos egoístas a aproximarse a lo que es mejor para el paciente.

Abstract: Culicoides sonorensis biting midges are well-known agricultural pests and transmission vectors of arboviruses such as vesicular stomatitis virus (VSV). The epidemiology of VSV is complex and encompasses a broad range of vertebrate hosts, multiple routes of transmission, and diverse vector species. In temperate regions, viruses can overwinter in the absence of infected animals through unknown mechanisms, to reoccur the next year. Non-conventional routes for VSV vector transmission may help explain viral maintenance in midge populations during inter-epidemic periods and times of adverse conditions for bite transmission. In this study, we examined whether VSV could be transmitted venereally between male and female midges. Our results showed that VSV-infected females could venereally transmit virus to uninfected naïve males at a rate as high as 76.3% (RT-qPCR), 31.6% (virus isolation) during the third gonotrophic cycle. Additionally, VSV-infected males could venereally transmit virus to uninfected naïve females at a rate as high as 76.6% (RTqPCR), 49.2% (virus isolation). Immunofluorescent staining of micro-dissected reproductive organs, immunochemical staining of midge histological sections, examination of internal reproductive organ morphology, and observations of mating behaviors were used to determine relevant anatomical sites for virus location and to hypothesize the potential mechanism for VSV transmission in C. sonorensis midges through copulation. Resumen: Los Culicoides son plagas agrícolas bien conocidas y vectores de transmisión de arbovirus como el virus de la estomatitis vesicular (VSV). La epidemiología de VSV es compleja y abarca una amplia gama de hospedadores vertebrados, múltiples rutas de transmisión y diversas especies de vectores. En las regiones templadas, los virus pueden invernar en ausencia de animales infectados a través de mecanismos desconocidos, para volver a ocurrir el próximo año. Las rutas no convencionales para la transmisión del VSV pueden ayudar a explicar el mantenimiento viral en las poblaciones de vectores durante los períodos interepidémicos y los momentos de condiciones adversas para la transmisión por picadura. En este estudio, examinamos si VSV podría transmitirse de forma venérea entre Culicoides machos y hembras. Nuestros resultados mostraron que las hembras infectadas con VSV podían transmitir el virus de forma venérea a machos no infectados a una tasas tan altas como 76,3% (RT-qPCR) o 31,6% (aislamiento del virus) durante el tercer ciclo gonotrófico. Además, los machos infectados con VSV podrían transmitir el virus a hembras no infectadas a tasas entre 76,6% (RT-qPCR) y 49,2% (aislamiento del virus). Adicionalmente se utilizaron tinción inmunofluorescente de órganos reproductores micro-disecados, tinción inmunoquímica de secciones histológicas de Culicoides para examinar la morfología de órganos reproductores y se hicieron observaciones de los comportamientos de apareamiento para determinar los sitios anatómicos relevantes para la ubicación del virus y para formular hipótesis sobre el mecanismo potencial de transmisión del VSV en C. sonorensis a través de la cópula.

Abstract: The article analyses the Resurrection of Christ, a fresco commissioned from Pinturicchio by Pope Alexander VI in 1492 as part of his project to renovate the Borgia Apartments in the Vatican. The analysis focuses on a detail of the painting: the figures of what seems to be a group of indigenous warriors located at the centre of the fresco. The main purpose of the paper is to identify the iconographic meaning and sources of this particular image. The central claim is that Pinturicchio used specific scenes from Christopher Columbus’s Diario to create, biased by a misconception of the New World, the first painted image of America in Europe.

Abstract: As the demand for English language skills among non-native speakers globally has grown steadily so too has the number of ‘global textbooks’ for ELT aimed at a world market. Concurrently, critical perspectives of the expansion of English have begun to challenge the view that native speaker contexts ‘own’ English. Based on the aforementioned, and on reflective approaches to culture, our objective is to analyze critically the representations of speakers of English as a second or foreign language offered by two global ELT textbooks, to discuss the issues of essentialization and reproduction of stereotypes about the “nonnative” speakers of English and their sociocultural characteristics in the constructed image. To achieve this purpose, we apply a methodology based on a sociocognitive approach to Critical Discourse Analysis (CDA) (Van Dijk, 2013), the concept of sociocultural knowledge as stated by the Common European Framework of Reference for Languages (CEFR), and critical perspectives of culture according to Holliday, Kullman, and Hyde (2004). Our findings indicate that, though the books include ‘non-native’ speakers in an attempt to address multiculturalism, their representation is generic, portraying a reified image of their sociocultural traits and presenting diversity mostly through national labels.

Abstract: The conservation of migratory species poses significant challenges that may be countered by detailed knowledge about the sites used by migrants throughout the annual cycle. We present the rst GPS-tracking data on the migration of declining Caspian terns Hydroprogne caspia breeding in the Baltic Sea. For 39 Caspian terns from colonies along a latitudinal gradient from 57 to 65°N, we identified key migratory routes, stopovers and wintering areas. In autumn these seabirds migrated using coastal and freshwater stopovers along six routes to reach their wintering areas across the Sahel, the Nile River Basin and the southern Iberian Peninsula. In spring, adults returned to the breeding grounds in the Baltic using a time optimizing strategy by reducing time at stopover by 78%, whereas most subadults remained sedentary and some performed only partial return migrations. Of the stopover sites used in both seasons, 58% are protected and have a reported management plan. Conservation strategies in wintering areas, stopover sites that are not protected or had not been previously recognized, and the inclusion of the species in important migratory yways across Europe and Africa will be important to prevent further population declines of a species that depends on aquatic habitats.

Abstract: Biluminescent organic emitters show simultaneous fluorescence and phosphorescence at room temperature. So far, the optimization of the room-temperature phosphorescence in these materials has drawn the attention of research. However, the continuous-wave operation of these emitters will consequently turn them into systems with vastly imbalanced singlet and triplet populations, which is due to the respective excited-state lifetimes. This study reports on the exciton dynamics of the biluminophore NPB (N,N′-di(1-naphthyl)-N,N′-diphenyl-(1,1-biphenyl)-4,4-diamine). In the extreme case, the singlet and triplet exciton lifetimes stretch from 3 ns to 300 ms, respectively. Through sample engineering and oxygen quenching experiments, the triplet exciton density can be controlled over several orders of magnitude, allowing us to study exciton interactions between singlet and triplet manifolds. The results show that singlet−triplet annihilation reduces the overall biluminescence efficiency already at moderate excitation levels. Additionally, the presented system represents an illustrative role model to study excitonic effects in organic materials.