Resumen: Uno de los grandes desafíos de las sociedades occidentales modernas, es justamente, la búsqueda constante de escenarios que permitan resolver los conflictos de manera pacífica a través del diálogo respetuoso, abierto y constructivo. Es así como se han plateado mecanismos como la conciliación, el arbitraje y la amigable composición para su resolución. Sin embargo, el uso de estos medios en ocasiones se ve retado dado el incesante dinamismo social, la aparición de nuevos conflictos y el uso reiterativo de formas tradicionales de solución de estos. Coetáneamente entre las comunidades indígenas existen normas consuetudinarias, procedimientos ancestrales e instituciones como la palabra, que han ayudado a preservar el orden y la convivencia, empleando una sabiduría ancestral basada en la observación de la naturaleza, la autoridad ejercida con responsabilidad y el uso de la retórica y la estética del lenguaje como herramientas para mantener el acercamiento y el entendimiento mutuo entre las familias y los eirruku wayuu. Los indígenas asentados en la península de La Guajira que comprende el departamento de La Guajira, al norte de Colombia y en el noroeste del estado Zulia en Venezuela conocidos como wayuu, se constituyen en la etnia más numerosa de ambos países y en un gran referente de estudio por la existencia de una cultura jurídica consuetudinaria basada en un sistema normativo milenario y en la insigne figura del Pütchipü´üi como mediador y tejedor de la palabra entre los miembros de esta comunidad, para asegurar el orden, la justicia y su supervivencia en un mundo cada vez más hostil y amenazante de sus costumbres y tradiciones. Abstract: One of the great challenges of modern western societies is precisely the constant search for scenarios that allow conflicts to be resolved peacefully through respectful, open and constructive dialogue. This is how mechanisms such as conciliation, arbitration and friendly composition have been established for its resolution. However, the use of these means is sometimes challenged given the incessant social dynamism, the appearance of new conflicts and the repetitive use of traditional ways of solving them. At the same time, among indigenous communities, there are customary norms, ancestral procedures, and institutions such as the word, which have helped to preserve order and coexistence, using an ancestral wisdom based on the observation of nature, the authority exercised with responsibility and the use of the rhetoric and the aesthetics of language as tools to maintain rapprochement and mutual understanding between families and the eirruku wayuu. The indigenous people settled in the La Guajira peninsula, which includes the department of La Guajira, in the north of Colombia and in the northwest of the Zulia state in Venezuela, known as wayuu, are the most numerous ethnic group in both countries and a great reference of study for the existence of a customary legal culture based on a millenary normative system and on the distinguished figure of the Pütchipü´üi as mediator and weaver of the word among the members of this community, to ensure order, justice and their survival in a world increasingly hostile and threatening of its customs and traditions.

Abstract: Here we systematically investigate the CO2 and H2 activation and dissociation on small CunZn{0/+} (n=3-6) clusters using Density Functional Theory. We show that Cu6Zn is a superatom, displaying an increased HOMO-LUMO gap and is inert towards CO2 or H2 activation or dissociation. While other neutral clusters weakly activate CO2, the cationic clusters preferentially bind the CO2 in monodentate nonactivated way. Notably, Cu4Zn allows for the dissociation of activated CO2, whereas larger clusters destabilize all activated CO2 binding modes. Conversely, H2 dissociation is favored on all clusters examined, except for Cu6Zn. Cu3Zn+ and Cu4Zn, favor the formation of formate through the H2 dissociation pathway rather than CO2 dissociation. These findings suggest the potential of these clusters as synthetic targets and underscore their significance in the realm of CO2 hydrogenation. Resumen: En este estudio, llevamos a cabo una investigación sistemática sobre la activación y disociación del CO2 y H2 en pequeños clusters de CunZn{0/+} (n=3-6) utilizando la Teoría del Funcional de la Densidad. Demostramos que Cu6Zn es un superátomo, exhibiendo un aumento en la brecha HOMO-LUMO y es inerte ante la activación y disociación tanto del CO2 como del H2. Mientras que otros clusters neutros activan débilmente el CO2, los clusters catiónicos tienden a enlazar preferentemente el CO2 de manera monodentada no activada. Notablemente, Cu4Zn permite la disociación del CO2 activado, mientras que clusters más grandes desestabilizan todos los modos de enlace activados del CO2. Por otro lado, la disociación del H2 es favorecida en todos los clusters examinados, excepto para Cu6Zn. Cu3Zn+ y Cu4Zn favorecen la formación del ion formato a través de la ruta de disociación del H2 en lugar de la disociación del CO2. Estos hallazgos sugieren el potencial de estos clusters como objetivos sintéticos y subrayan su importancia en el ámbito de la hidrogenación del CO2.

Abstract: Resistance to protoporphyrinogen oxidase (PPO) inhibitors in Palmer amaranth is a majorconcern, given the high selection pressure and increasing number of populations with reducedsensitivity to PPO herbicides in the US. We evaluated the effect of five soil-applied herbicides onPalmer amaranth (Amaranthus palmeriS. Wats.) populations collected in 2014 and 2015 in Arkansas,USA. Soil-applied saflufenacil, sulfentrazone, and flumioxazin reduced the seedling emergence 91–100%; however, fomesafen and oxyfluorfen showed reduced (63–90%) efficacy on some populations.Target-site mutation (TSM) is the major mechanism of resistance to PPO herbicides; therefore, sixpopulations showing resistance to soil-applied fomesafen were selected for molecular investigations.A total of 81 survivors were genotyped for all known resistance-conferring mutations. A total of 64%and 36% survivors had single and double TSMs, respectively, with 69% of plants carrying TSM inboth alleles ofPPO2. Three survivors from two populations showed an additional copy ofPPO2,whereas all other survivors had one copy. Expression analysis showed 3- to 6-fold upregulation ofPPO2in all plants from resistant populations tested. Transgenic overexpression of WT-ApPPO2anddG210-Apppo2inA. thalianaconfirmed the reduced sensitivity to soil-applied fomesafen compared tothe wild type. Collectively, PPO inhibitors applied pre-emergence are still effective in controllingpopulations resistant to foliar-applied PPO herbicides. Mechanically, elevated expression of resistantPPO2, alongside functional TSM, contribute to reduced sensitivity to soilapplied fomesafen.

Abstract: In this paper, we introduce and numerically simulate a quantum field theoretical phenomenon called the gauge ``slingshot"" effect and study its production of gravitational waves. The effect occurs when a source, such as a magnetic monopole or a quark, crosses the boundary between the Coulomb and confining phases. The corresponding gauge field of the source, either electric or magnetic, gets confined into a flux tube stretching in the form of a string (cosmic or a QCD type) that attaches the source to the domain wall, separating the two phases. The string tension accelerates the source towards the wall as sort of a slingshot. The slingshot phenomenon is also exhibited by various sources of other co-dimensionality, such as cosmic strings confined by domain walls or vortices confined by Z_2 strings. Apart from the field-theoretic value, the slingshot effect has important cosmological implications, as it provides a distinct source for gravitational waves. The effect is expected to be generic in various standard model extensions, such as grand unification.

Abstract: We study the interactions between ’t Hooft-Polyakov magnetic monopoles and the domain walls formed by the same order parameter within an SU(2) gauge theory. We observe that the collision leads to the erasure of the magnetic monopoles, as suggested by Dvali et al. [Phys. Rev. Lett. 80, 2281 (1998)]. The domain wall represents a layer of vacuum with un-Higgsed SU(2) gauge symmetry. When the monopole enters the wall, it unwinds, and the magnetic charge spreads over the wall. We perform numerical simulations of the collision process and, in particular, analyze the angular distribution of the emitted electromagnetic radiation. As in the previous studies, we observe that erasure always occurs. Although not forbidden by any conservation laws, the monopole never passes through the wall. This is explained by entropy suppression. The erasure phenomenon has important implications for cosmology, as it sheds a very different light on the monopole abundance in postinflationary phase transitions and provides potentially observable imprints in the form of electromagnetic and gravitational radiation. The phenomenon also sheds light on fundamental aspects of gauge theories with coexisting phases, such as confining and Higgs phases.

Abstract: In this work, we study the annihilation of a pair of ‘t Hooft-Polyakov monopoles due to confinement by a string. We analyze the regime in which the scales of monopoles and strings are comparable. We compute the spectrum of the emitted gravitational waves and find it to agree with the previously calculated pointlike case for wavelengths longer than the system width and before the collision. However, we observe that in a head-on collision, monopoles are never recreated. Correspondingly, not even once the string oscillates. Instead, the system decays into waves of Higgs and gauge fields. We explain this phenomenon by the loss of coherence in the annihilation process. Due to this, the entropy suppression makes the recreation of a monopole pair highly improbable. We argue that in a similar regime, analogous behavior is expected for the heavy quarks connected by a QCD string. There too, instead of restretching a long string after the first collapse, the system hadronizes and decays in a high multiplicity of mesons and glueballs. We discuss the implications of our results.

Abstract: Black holes are considered exceptional due to their time evolution and information processing. However, it was proposed recently that these properties are generic for objects, the so-called saturons, that attain the maximal entropy permitted by unitarity. The present paper verifies this connection within a renormalizable SU(N) invariant theory. We show that the spectrum of the theory contains a tower of bubbles representing bound states of SU(N) Goldstones. Despite the absence of gravity, a saturated bound state exhibits a striking correspondence with a black hole: Its entropy is given by the Bekenstein-Hawking formula; semiclassically, the bubble evaporates at a thermal rate with a temperature equal to its inverse radius; the information retrieval time is equal to Page’s time. The correspondence goes through a trans-theoretic entity of the Poincaré Goldstone. The black hole–saturon correspondence has important implications for black hole physics, both fundamental and observational.

Abstract: Vorticity has recently been suggested to be a property of highly-spinning black holes. The connection between vorticity and limiting spin represents a universal feature shared by objects of maximal microstate entropy, so-called saturons. Using QQ-ball-like saturons as a laboratory for black holes, we study the collision of two such objects and find that vorticity can have a large impact on the emitted radiation as well as on the charge and angular momentum of the final configuration. As black holes belong to the class of saturons, we expect that the formation of vortices can cause similar effects in black hole mergers, leading to macroscopic deviations in gravitational radiation. This could leave unique signatures detectable with upcoming gravitational-wave searches, which can thereby serve as a portal to macroscopic quantum effects in black holes. Note: ancillary video at https://youtu.be/t29WUvZM-io

Abstract: The interaction of defects can lead to a phenomenon of erasure. During this process, a lower-dimensional object gets absorbed and dissolved by a higher-dimensional one. The phenomenon is very general and has a wide range of cosmological and fundamental implications. In particular, all types of strings, such as cosmic strings, QCD flux tubes, or fundamental strings, get erased when encountering a defect, either solitonic or a D-brane that deconfines their fluxes. This leads to a novel mechanism of cosmic string breakup, accompanied by gravitational and electromagnetic radiations. The arguments based on loss of coherence and the entropy count suggest that the erasure probability is very close to one, and strings never make it through the deconfining layer. We confirm this by a numerical simulation of the system, which effectively captures the essence of the phenomenon: a 2+1- dimensional problem of interaction between a Nielsen-Olesen vortex of a U(1) Higgs model and a domain wall, inside which the U(1) gauge group is un-Higgsed, and the magnetic flux is deconfined. In accordance with the entropy argument, in our simulation, the vortex never makes it across the wall.

Abstract: Patients with traumatic brain injury (TBI) are at an increased risk of developing chronic neurodegenerative diseases, including Alzheimer’s disease (AD), an association thought to be related to several factors, including altered production and clearance of apolipoprotein E (ApoE) and amyloid-? (A?). We previously reported decreased CSF expression of proteins related to cholesterol metabolism in patients with ABI, which may potentially lead to reduced neuro-steroid production, increased risk of neurodegenerative disease, and worse functional outcomes. In this post hoc analysis, ApoE (ApoEelisa), amyloid beta 1–40 (A?1–40), and amyloid beta 1–42 (A?1–42) concentrations were measured in vCSF taken from an external ventricular drain on Days 1–5 after non-traumatic ABI. The vCSF concentrations of ApoE were measured using a commercial enzyme linked immunosorbent assay (ELISA) test . The vCSF concentrations of A?1–40 and A?1–42 were also measured using a commercial ELISA test, with 50 ?l/patient (robotic pipette) per sample in duplicate using A?1–40 and A?1–42 monoclonal antibody, respectively. Day 1 ApoEelisa concentrations were significantly lower (p < 0.01) in patients with non-traumatic ABI than in control patients. vCSF A?1–40 (p < 0.001) and A?1–42 (p < 0.001) concentrations were also lower in the ABI patients. Day 1–5 ApoEswath protein expressions were significantly lower in patients with nontraumatic ABI than in controls (p < 0.0001). APLP1 values, but not those of APP or APLP2, were also significantly lower in non-traumatic ABI (p < 0.0001) throughout the 5-day period. These findings suggest that specific precursors of neurotoxic A? may be expressed in the early phase of nontraumatic ABI, such as that caused by vascular injury after ischemic or hemorrhagic strokes. Resumen: Los pacientes con lesión cerebral traumática (LCA traumática) tienen un mayor riesgo de desarrollar enfermedades neurodegenerativas crónicas, incluida la enfermedad de Alzheimer (EA), una asociación que se cree que está relacionada con varios factores, incluida la producción alterada y la eliminación de la apolipoproteína E (ApoE). y ?-amiloide (A?). Anteriormente informamos una disminución de la expresión en el LCR de proteínas relacionadas con el metabolismo del colesterol en pacientes con LCA, lo que potencialmente puede conducir a una reducción de la producción de neuroesteroides, un mayor riesgo de enfermedades neurodegenerativas y peores resultados funcionales. En este análisis post hoc, se midieron las concentraciones de ApoE (ApoEelisa), beta amiloide 1–40 (A?1–40) y beta amiloide 1–42 (A?1–42) en vCSF extraído de un drenaje ventricular externo en los días 1 a 5 después LCA no traumática. Las concentraciones de ApoE en vCSF se midieron utilizando una prueba comercial de ensayo inmunoabsorbente ligado a enzimas (ELISA). Las concentraciones de vCSF de A?1–40 y A?1–42 también se midieron utilizando una prueba ELISA comercial, con 50 ?l/paciente (pipeta robótica) por muestra por duplicado utilizando los anticuerpos monoclonales A?1–40 y A?1–42, respectivamente. Las concentraciones de ApoEelisa en el día 1 fueron significativamente más bajas (p <0,01) en pacientes con LCA no traumática que en pacientes de control. Las concentraciones de vCSF A?1–40 (p <0,001) y A?1–42 (p <0,001) también fueron más bajas en los pacientes con LCA. Las expresiones de la proteína ApoEswath de los días 1 a 5 fueron significativamente menores en pacientes con LCA no traumática que en los controles (p <0,0001). Los valores de APLP1, pero no los de APP o APLP2, también fueron significativamente más bajos en la LCA no traumática (p <0,0001) durante el período de 5 días. Estos hallazgos sugieren que precursores específicos de A? neurotóxico pueden expresarse en la fase temprana de una LCA no traumática, como la causada por una lesión vascular después de un accidente cerebrovascular isquémico o hemorrágico.