Este libro es una continuación del anterior: Cómo ser esclerótica y no morir en el intento. En él hay muchas anécdotas y vivencias personales que ayudan a ver las cosas de otra manera, y que por difícil que sea el episodio, nunca puede faltar una sonrisa, y el sentido del humor.

El tractament d'implants dentals s'ha convertit en una pràctica comuna en clíniques dentals. Juntament amb l'augment de la demanda, i una varietat més àmplia d'opcions de tractament, existeix la necessitat de proporcionar més informació als pacients, explicant les diferents opcions terapèutiques i els resultats que poden aconseguir-se amb els dos aspectes, tant el funcional com l'estètic. A través d'aquest manual, els autors del llibre pretenen simplificar i resumir el tractament dels implants. Les imatges que arrepleguen són clares i fàcils d'entendre, i faciliten la descripció i explicació dels...

Abstract: The aim of this work was to investigate the effect of two post-curing methods on the mechanical properties of a 3D-printed denture base material. Additionally, to compare the mechanical properties of that 3D-printed material with those of conventional autopolymerizing and a heat-cured denture base material. A resin for 3D-printing denture base (Imprimo ®), a heat-polymerizing acrylic resin (Paladon ® 65), and an autopolymerizing acrylic resin (Palapress ®) were investigated. Flexural strength, elastic modulus, fracture toughness, work of fracture, water sorption, and water solubility were evaluated. The 3D-printed test specimens were post-cured using two different units (Imprimo Cure ® and Form Cure ®). The tests were carried out after both dry and 30 days water storage. Data were collected and statistically analyzed. Resin type had a significant effect on the flexural strength, elastic modulus, fracture toughness, and work of fracture (p < 0.001). The flexural strength and elastic modulus for the heat-cured polymer were significantly the highest among all investigated groups regardless of the storage condition (p < 0.001). The fracture toughness and work of fracture of the 3Dprinted material were significantly the lowest (p < 0.001). The heat-cured polymer had the lowest significant water solubility (p < 0.001). The post-curing method had an impact on the flexural strength of the investigated 3D-printed denture base material. The flexural strength, elastic modulus, fracture toughness, work of fracture of the 3D-printed material were inferior to those of the heat-cured one. Increased post-curing temperature may enhance the flexural properties of resin monomers used for 3D-printing dental appliances. Resumen: El objetivo de este trabajo fue investigar el efecto de dos métodos de poscurado en la Propiedades mecánicas de un material base para prótesis dental impreso en 3D. Además, para comparar la mecánica propiedades de ese material impreso en 3D con las de la autopolimerización convencional y un curado por calor material base de la dentadura postiza. Una resina para la impresión 3D de bases de prótesis dentales (Imprimo ®), un acrílico termopolimerizable Se investigaron una resina (Paladon ® 65) y una resina acrílica autopolimerizable (Palapress ®). Flexión Resistencia, módulo elástico, tenacidad a la fractura, trabajo de fractura, sorción de agua y solubilidad en agua. fueron evaluados. Las muestras de prueba impresas en 3D se curaron posteriormente utilizando dos unidades diferentes (Imprimo Cure® y Form Cure®). Las pruebas se llevaron a cabo después de un almacenamiento en seco y durante 30 días en agua. Datos fueron recolectados y analizados estadísticamente. El tipo de resina tuvo un efecto significativo sobre la resistencia a la flexión, módulo elástico, tenacidad a la fractura y trabajo de fractura (p < 0,001). La resistencia a la flexión y El módulo elástico para el polímero curado con calor fue significativamente el más alto entre todos los investigados. grupos independientemente de la condición de almacenamiento (p < 0,001). La tenacidad a la fractura y el trabajo de fractura. del material impreso en 3D fueron significativamente los más bajos (p <0,001). El polímero curado por calor tenía la solubilidad en agua significativa más baja (p < 0,001). El método de poscurado tuvo un impacto en la Resistencia a la flexión del material de base de la dentadura postiza impreso en 3D investigado. La resistencia a la flexión, elástica. El módulo, la tenacidad a la fractura y el trabajo de fractura del material impreso en 3D fueron inferiores a los del curado con calor. El aumento de la temperatura de poscurado puede mejorar las propiedades de flexión de la resina monómeros utilizados para aparatos dentales de impresión 3D.

Abstract: 3D printing technologies enable medicine customization adapted to patients' needs. There are several 3D printing techniques available, but majority of dosage forms and medical devices are printed using nozzle-based extrusion, laser-writing systems, and powder binder jetting. 3D printing has been demonstrated for a broad range of applications in development and targeting solid, semi-solid and locally applied or implanted medicines. 3D printed solid dosage forms allow the combination of one or more drugs within the same solid dosage form to improve patient compliance, facilitate deglutition, tailor the release profile, or fabricate new medicines for which no dosage form is available. Sustained release 3D-printed implants, stents and medical devices have been used mainly for joint replacement therapies, medical prostheses, and cardiovascular applications. Locally applied medicines such as wound dressing, microneedles, and medicated contact lenses have also been manufactured using 3D printing techniques. The challenge is to select the 3D printing tech-nique most suitable for each application and the type of pharmaceutical ink that should be devel-oped that possesses the required physicochemical and biological performance. The integration of biopharmaceuticals and nanotechnology-based drugs along with 3D printing (""Nanoprinting"") brings printed personalized nanomedicines within the most innovative perspectives for the coming years. Continuous manufacturing through the use of 3D-printed microfluidic chips facilitates their translation into clinical practice.

Una obra de referencia tanto para enfermos de cáncer como para quienes deseen saber más sobre la enfermedad y profundizar en uno de los enigmas biológicos más complejos y fascinantes que existen. El cáncer es una de las enfermedades más frecuentes, y seguro que entre quienes nos rodean conocemos algunos casos. Sin embargo, incluso el nombre despierta recelos, y cuesta hablar de él abiertamente. ¿Qué es el cáncer? ¿Hay cada vez más casos? ¿Es lo mismo un cáncer que un tumor? ¿Cuánto tarda en formarse un cáncer? ¿Cuáles son los principales factores de riesgo para desarrollar uno? ¿Es hereditario? ¿Y...

Las posibilidades terapéuticas que ofrece la nueva genética son ingentes, pero, a su vez, inquietantes. La investigación y experimentación genéticas provocan grandes expectativas, pero también más reticencias que ninguna otra revolución técnica de la historia precedente. Y es que, realmente, es mucho lo que hay en juego. Hablamos de poder alterar y modificar no sólo la naturaleza exterior, vegetal o animal, sino también nuestra propia naturaleza humana. Además, el acceso y el uso de la información genética pueden dar lugar eventualmente a situaciones lesivas para el ámbito de la privacidad e intimidad genética, por medio de discriminación o estigmatización.

Background: The effect of early surgery in elderly patients with hip fractures has been controversial during the last five decades due to equivocal evidence both in favour and against it. The objective of this thesis is to systematically assess all the available evidence on the effect(s) of early surgery compared with delayed surgery in elderly patients with hip fractures. Methods: Searches for randomised controlled trials (RCTs) or prospective observational studies were conducted from inception to July 2017 in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (OVID), EMBASE (OVID), and they were complemented with list of references searching, review of both clinical trials registers and archives of orthopaedic meetings. Two reviewers independently selected studies for inclusion, extracted data and evaluated risk of bias; and a third reviewer resolved discrepancies. Risk ratios (RR) were calculated for dichotomous data, and mean difference (MD) or standardised mean difference (SMD) was calculated for continuous data. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results: 39 studies were included with 51,857 participants (range of mean age: 74 to 93 years) comparing early versus delayed surgery. Three studies were RCTs and 36 were observational studies. The evidence from RCTs and observational studies showed that early surgery reduces risk of all-cause 3 mortality in elderly patients with a hip fracture (RR 0.73, 95% confidence interval (CI) 0.65 to 0.83; I2 = 67%; number needed to treat for benefit (NNTB) 20; low quality of evidence). Observational studies showed reduced risk of all-cause mortality by early surgery at 6 (RR 0.77, 95% CI 0.66 to 0.91; I2 = 56%; very low quality of evidence) and 12 months postoperative (RR 0.69, 95% CI 0.55 to 0.87; I2 = 76%; very low quality of evidence), and when surgery is performed within the first 48 hours upon hospital admission (RR 0.72, 95% CI 0.62 to 0.84; I2 = 65%; very low quality of evidence). Observational studies also showed a reduction of complications (RR 0.61, 95% CI 0.51 to 0.73; I2 = 64%; very low quality of evidence) and length of hospital stay (MD -5.06, 95% CI -6.52 to -3.60; I2 = 87%; very low quality of evidence) by early surgery, but the evidence was uncertain for functionality (SMD 0.05, 95% CI -0.04 to 0.14; I2 = 0%; low quality of evidence) and pain (RR 0.89, 95% CI 0.67 to 1.17; I2 = 0%; very low quality of evidence). RCTs showed that early surgery reduces length of stay (MD -6.73, 95% CI -12.92 to -0.54; I2 = 54%; very low quality of evidence) and improves functionality (SMD 0.32, 95% CI 0.04 to 0.59; I2 = 5%; low quality of evidence). Conclusions: Low-quality evidence showed that early surgery reduces all-cause mortality at 6 and 12 months post-surgery, especially when it is performed during the first 48 hours after hospital admission. There was very low-quality evidence of a reduction in complications including pneumonia and pressure sores, and low-quality evidence for a reduced risk of urinary tract infection for early compared with delayed surgery. Reductions in length of hospital stay and improvement of postoperative functionality with early surgery were also observed but with very low- and low-quality of evidence respectively. There was very low-quality evidence for no effect of early surgery on postoperative pain.